Document Detail


Effects of the mixed-action kappa/mu opioid agonist 8-carboxamidocyclazocine on cocaine- and food-maintained responding in rhesus monkeys.
MedLine Citation:
PMID:  15588733     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study evaluated the effects of 8-carboxamidocyclazocine (8-CAC), a novel mixed-action kappa/mu agonist with a long duration of action, on food- and cocaine-maintained responding in rhesus monkeys to assess the potential utility of 8-CAC as a medication for the treatment of cocaine dependence. The effects of acute and chronic (10 days) 8-CAC were examined in rhesus monkeys responding under a multiple schedule for both cocaine and food reinforcement. Acute 8-CAC (0.032-0.56 mg/kg, i.m.) dose-dependently eliminated cocaine-maintained responding in all three monkeys. However, doses of 8-CAC that decreased cocaine self-administration typically also decreased food-maintained responding, and 8-CAC-induced decreases in cocaine self-administration diminished during chronic 8-CAC treatment. These results confirm that 8-CAC acutely decreases cocaine self-administration. However, non-selective effects of 8-CAC on food-maintained responding and tolerance to 8-CAC effects on cocaine self-administration may limit its potential for the treatment of cocaine dependence.
Authors:
Glenn W Stevenson; Mark P Wentland; Jean M Bidlack; Nancy K Mello; S Stevens Negus
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of pharmacology     Volume:  506     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-05-06     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  133-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cocaine / pharmacology*
Conditioning, Operant / drug effects*
Cyclazocine / analogs & derivatives*,  pharmacology*
Dose-Response Relationship, Drug
Female
Food*
Hypnotics and Sedatives / pharmacology
Macaca mulatta
Male
Receptors, Opioid, kappa / agonists*
Receptors, Opioid, mu / agonists*
Reinforcement Schedule
Reward*
Vomiting / chemically induced
Grant Support
ID/Acronym/Agency:
DA012180/DA/NIDA NIH HHS; K05-DA00101/DA/NIDA NIH HHS; K05-DA00360/DA/NIDA NIH HHS; R01-DA02519/DA/NIDA NIH HHS; T32-DA07252/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/8-carboxamidocyclazocine; 0/Hypnotics and Sedatives; 0/Receptors, Opioid, kappa; 0/Receptors, Opioid, mu; I5Y540LHVR/Cocaine; J5W1B1159C/Cyclazocine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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