| Effects of mitomycin C on macromolecular synthesis in Escherichia coli. | |
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MedLine Citation:
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PMID: 5335968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When cells of Escherichia coli B growing in a glucose-synthetic medium were treated with mitomycin C, the effects produced by the antibiotic varied, depending on the concentration. When the concentration was reduced to less than 0.1 mug/ml, the action of the antibiotic was bacteriostatic; cell elongation resulted, but no effect on the synthesis of cellular macromolecules was apparent. At higher levels (more than 5 mug/ml), mitomycin C was highly bactericidal and inhibited deoxyribonucleic acid synthesis almost completely. The exposure of growing cells to a bactericidal level of mitomycin C resulted also in a delayed inhibition of the synthesis of ribonucleic acid (RNA) and protein. The capacity of the treated cells to synthesize beta-galactosidase inducibly in a medium free from a carbon source remained constant for the first 30 min and then was destroyed progressively with time. Prolonged incubation with the bactericidal level of mitomycin C caused a degradation of cellular nucleic acids, particularly RNA. The degraded nucleic acid components were eventually released into the medium. |
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Authors:
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H Suzuki; W W Kilgore |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of bacteriology Volume: 93 ISSN: 0021-9193 ISO Abbreviation: J. Bacteriol. Publication Date: 1967 Feb |
Date Detail:
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Created Date: 1967-05-12 Completed Date: 1967-05-12 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985120R Medline TA: J Bacteriol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 675-82 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Proteins
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biosynthesis Carbon Isotopes DNA, Bacterial / biosynthesis* Escherichia coli / drug effects*, growth & development, metabolism* Glycoside Hydrolases / analysis Mitomycins / pharmacology* RNA, Bacterial / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Carbon Isotopes; 0/DNA, Bacterial; 0/Mitomycins; 0/RNA, Bacterial; EC 3.2.1.-/Glycoside Hydrolases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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