Document Detail

Effects of mistletoe (Viscum album L., Loranthaceae) extracts on arterial blood pressure in rats treated with atropine sulfate and hexocycline.
MedLine Citation:
PMID:  19172455     Owner:  NLM     Status:  MEDLINE    
Acute effects of different extracts of mistletoe stem (Viscum album) were investigated on values of arterial blood pressure in Wistar rats. Arterial blood pressure was registered by direct method in the left carotid artery and the investigated extracts (total ethanol, ether and ethyl acetate) of mistletoe stem were administered into the right jugular vein. The total ethanol extract exhibited the best effect even on the lowest applied concentration (3.33 x 10(-5) mg kg(-1)) and significantly decreased the blood pressure after applied concentration 1.00 x 10(-3) mg kg(-1). On the contrary, the ether and ethyl acetate extracts exhibited notable activity only by higher administered doses. Atropine as a nonselective blocker of muscarinic receptors reduced the hypotensive effects of ethanol extract of mistletoe. Hexocycline, a selective blocker of muscarine receptors, significantly raised blood pressure and decreased the hypotensive effect of ethanol extract of mistletoe on arterial blood pressure in rats.
Mirjana Radenkovic; Vesna Ivetic; Mira Popovic; Suzana Brankovic; Ljiljana Gvozdenovic
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  31     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-27     Completed Date:  2009-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11-9     Citation Subset:  IM    
Department of Physiology, University of Nis, Serbia.
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MeSH Terms
Antihypertensive Agents / pharmacology
Atropine / pharmacology
Blood Pressure / drug effects*
Muscarinic Antagonists / pharmacology
Piperazines / pharmacology
Plant Extracts / isolation & purification,  pharmacology
Rats, Wistar
Viscum album*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Muscarinic Antagonists; 0/Piperazines; 0/Plant Extracts; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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