Document Detail

Effects of missense mutation on structure and function of photoreceptor.
MedLine Citation:
PMID:  22516823     Owner:  NLM     Status:  MEDLINE    
Phytochromes (PHYs) are photoreceptors of the red (R ~660 nm) and far-red (FR ~730 nm) light, and they control a wide range of responses affecting crucial aspects of plant life. There are five genes PHYA-PHYE encoding for phytochromes of different but overlapping function. One of these, PHYA has the unique function controlling specific responses in high irradiance far-red, as well as in very weak light. Appropriate PHYA functioning requires not only the photoreversibility of molecule but also the proper nuclear localization and degradation of receptor. Recently, we identified and described a mutant PHYA allele (phyA-5) in Arabidopsis thaliana, which showed reduced binding affinity to FHY1/FHL, the proteins regulating its nuclear transport, resulting in impaired nuclear localization and altered signaling under certain conditions. We present here a hypothesis to explain how the identified amino acid substitution may lead to structural changes manifested as altered signaling and phenotype displayed by the phyA-5 mutant.
Balázs Leitgeb; Vladyslava Sokolova; Eberhard Schäfer; András Viczián
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-04-20
Journal Detail:
Title:  Plant signaling & behavior     Volume:  7     ISSN:  1559-2324     ISO Abbreviation:  Plant Signal Behav     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-09-17     Completed Date:  2013-01-16     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101291431     Medline TA:  Plant Signal Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  589-91     Citation Subset:  IM    
Institute of Biophysics, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.
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MeSH Terms
Amino Acid Substitution*
Arabidopsis / genetics,  metabolism,  physiology*
Arabidopsis Proteins / genetics*,  metabolism
Cell Nucleus
Genes, Plant*
Mutation, Missense*
Phytochrome / metabolism
Phytochrome A / genetics*,  metabolism
Protein Binding
Protein Transport
Signal Transduction
Transcription Factors / metabolism
Reg. No./Substance:
0/Arabidopsis Proteins; 0/FHL protein, Arabidopsis; 0/FHY1 protein, Arabidopsis; 0/Phytochrome A; 0/Transcription Factors; 11121-56-5/Phytochrome

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