Document Detail


Effects of minimally invasive puncture and drainage of intracranial hematoma on the blood-brain barrier in patients with cerebral hemorrhage.
MedLine Citation:
PMID:  17393122     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of minimally invasive surgery on the blood-brain barrier (BBB) of 30 patients with cerebral hemorrhage were investigated. Difference of the BBB index and serum MBP concentration were assessed in 15 cases of conservative treatment group and 15 cases of minimally invasive surgery group. The BBB index in minimally invasive surgery group was significantly lower than in conservative treatment group (P<0.05), and the BBB index in the two treatment groups was significantly higher than in control group (P<0.01). Serum MBP concentration in minimally invasive surgery group was significantly lower than in conservative treatment group (P<0.05), and that in the two treatment groups was significantly higher than in control group (P<0.01). It was suggested the permeability of BBB in patients with cerebral hemorrhage was increased, and BBB index and serum MBP concentration in patients with cerebral hemorrhage were increased. Minimally invasive surgery can reduce the lesion of cytotoxicity to BBB and cerebral edema.
Authors:
Xiaojiang Huang; Shougang Guo; Wei Wang
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban     Volume:  27     ISSN:  1672-0733     ISO Abbreviation:  J. Huazhong Univ. Sci. Technol. Med. Sci.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-03-29     Completed Date:  2008-10-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101169627     Medline TA:  J Huazhong Univ Sci Technolog Med Sci     Country:  China    
Other Details:
Languages:  eng     Pagination:  101-3     Citation Subset:  IM    
Affiliation:
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. huangxiaojiang@sina.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Albumins / analysis,  cerebrospinal fluid
Biuret Reaction / methods
Blood-Brain Barrier / drug effects,  pathology*,  surgery*
Bromcresol Green / metabolism
Case-Control Studies
Drainage / methods
Enzyme-Linked Immunosorbent Assay
Female
Hematoma / etiology*,  radiography,  surgery
Humans
Indicators and Reagents / metabolism
Intracranial Hemorrhages / drug therapy,  pathology*,  radiography,  surgery*
Male
Middle Aged
Myelin Basic Proteins / blood
Spinal Puncture / methods
Treatment Outcome
Urokinase-Type Plasminogen Activator / therapeutic use
Chemical
Reg. No./Substance:
0/Albumins; 0/Indicators and Reagents; 0/Myelin Basic Proteins; 76-60-8/Bromcresol Green; EC 3.4.21.73/Urokinase-Type Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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