Document Detail

Effects of mineral-water supplementation on gastric emptying of solids in patients with functional dyspepsia assessed with the 13C-octanoic-acid breath test.
MedLine Citation:
PMID:  15532843     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Functional dyspepsia is a major problem in terms of prevalence and drug-therapy expenditures. In dyspeptic patients the symptoms are frequently caused by delayed gastric emptying. Conventional treatment is often inefficient. Mineral-water supplementation is prescribed for the treatment of this condition, but there is no concrete proof of its actual efficacy. The aim of this study was to evaluate the effect of supplementation with mineral waters with high mineral salt contents (Acqua Tettuccio, Acqua Regina, Montecatini Terme) on gastric emptying of solids and symptoms in patients with functional dyspepsia. METHODOLOGY: Eight patients with functional dyspepsia and two healthy (non-dyspeptic) controls were placed on high-mineral-content water supplementation (500 cc/day) for eight days. Before and after completion of the supplementation treatment, patient symptoms were scored and the 13C-octanoic-acid breath test was administered to assess gastric emptying. RESULTS: After the treatment, the dyspeptic subjects presented clear decreases in parameters of gastric emptying (half time and lag time) as well as an improvement in symptom scores. CONCLUSIONS: Health spa treatments based on consumption of waters with a high content of mineral salts seem to be capable of improving gastric emptying of solids in dyspeptics. Longer and longitudinal studies are needed to verify the persistence of this effect.
Marcello Anti; Maria Enrichetta Lippi; Luca Santarelli; Maurizio Gabrielli; Antonio Gasbarrini; Giovanni Gasbarrini
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  51     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2004 Nov-Dec
Date Detail:
Created Date:  2004-11-09     Completed Date:  2005-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1856-9     Citation Subset:  IM    
Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy.
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MeSH Terms
Breath Tests
Carbon Isotopes / diagnostic use
Case-Control Studies
Dyspepsia / drug therapy*,  epidemiology,  radionuclide imaging*
Follow-Up Studies
Gastric Emptying / drug effects*,  physiology
Middle Aged
Mineral Waters / therapeutic use*
Monitoring, Physiologic / methods
Octanoic Acids / diagnostic use
Reference Values
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Carbon Isotopes; 0/Octanoic Acids; 124-07-2/caprylic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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