Document Detail

Effects of a mineral antioxidant complex on clinical safety, body water, lactate response, and aerobic performance in response to exhaustive exercise.
MedLine Citation:
PMID:  20975106     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This investigation examined the safety and efficacy of a silica-based mineral antioxidant complex (MAC) that has been suggested to influence body water and buffer lactate.
METHODS: In a double-blind, randomized crossover design, male participants completed testing for 3 conditions: water only (baseline), rice flour (placebo), and MAC supplementation. Participants visited the laboratory on 5 occasions: familiarization, baseline, Testing Day 1, washout, and Testing Day 2. Baseline and Testing Days 1 and 2 consisted of fasting blood, pre- to postexercise body-water assessment and determination of VO2peak on a cycle ergometer. The supplementation protocols were separated by 1 wk and balanced to minimize an order effect.
RESULTS: No differences between conditions were found for heart rate, blood pressure, or serum-safety markers (p>.05). Before exercise there were no differences between conditions for total body water (TBW), intracellular water (ICW), or extracellular water (ECW). No significant interactive effects for supplementation and exercise were found for TBW, ICW, or ECW (p>.05). A time effect for TBW (p<.01) and ICW (p<.001) was present. Within-group changes in TBW occurred in the MAC condition, and within-group changes for ICW occurred in the MAC and placebo conditions. Ratings of perceived exertion and blood lactate increased (p<.05) with exercise. No significant effects were found for performance variables.
CONCLUSIONS: MAC supplementation had no impact on aerobic exercise performance and lactate response. Increases in TBW and ICW occurred after MAC consumption, but these changes appeared to have minimal physiological impact.
Vincent J Dalbo; Michael D Roberts; Scott E Hassell; Jordan R Moon; Chad M Kerksick
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of sport nutrition and exercise metabolism     Volume:  20     ISSN:  1526-484X     ISO Abbreviation:  Int J Sport Nutr Exerc Metab     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-26     Completed Date:  2010-11-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939812     Medline TA:  Int J Sport Nutr Exerc Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  381-92     Citation Subset:  IM    
School of Medicine and Applied Sciences, Central Queensland University, Rockhampton, Australia.
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MeSH Terms
Antioxidants / administration & dosage,  adverse effects,  pharmacology*
Bicycling / physiology
Body Water / metabolism*
Consumer Product Safety
Cross-Over Studies
Dietary Supplements
Double-Blind Method
Electric Impedance
Lactates / metabolism*
Minerals / administration & dosage,  adverse effects,  pharmacology*
Physical Exertion / drug effects*,  physiology
Silicon Dioxide / administration & dosage,  adverse effects,  pharmacology
Young Adult
Reg. No./Substance:
0/Antioxidants; 0/Lactates; 0/Minerals; 7631-86-9/Silicon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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