Document Detail

Effects of milrinone and sulmazole on left ventricular mechanoenergetics in canine hearts.
MedLine Citation:
PMID:  8891859     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The effect of cardiotonic drugs with calcium-sensitizing effect (Ca2+ sensitizers) on cardiac mechanoenergetics is not fully understood. Accordingly, the effects of milrinone (a phosphodiesterase inhibitor) and sulmazole (a calcium sensitizer with a phosphodiesterase-inhibiting effect) on left ventricular mechanics and energetics were studied. METHODS AND RESULTS: In excised, cross-circulated canine hearts, myocardial oxygen consumption (Vo2), left ventricular contractility index (Emax), and systolic pressure-volume area (a measure of ventricular total mechanical energy) were measured before and during administration of either drug. Milrinone significantly increased Emax by 108.7 +/- 45.9% (mean +/- SD), from 6.3 +/- 3.5 to 13.1 +/- 6.8 mmHg.mL-1.100 g (P < .05), and sulmazole, by 73.6 +/- 54.2%, from 6.3 +/- 2.6 to 10.3 +/- 2.9 mmHg.mL-1.100 g (P < .05). Milrinone significantly abbreviated the contraction duration (Tmax) from 171 +/- 19 ms to 153 +/- 20 ms (P < .05), whereas sulmazole did not (164 +/- 36 ms to 161 +/- 31 ms, not significant), suggesting that the inotropic mechanisms of these two drugs differed. However, both drugs significantly increased the Vo2 intercept of the Vo2/pressure-volume area relation (milrinone: 0.027 +/- 0.004 to 0.036 +/- 0.003 mL O2/beat/100 g, P < .05; sulmazole: 0.025 +/- 0.005 to 0.032 +/- 0.006 mL O2/beat/100 g, P < .05) without significantly changing the slope (reciprocal of contractile efficiency). This parallel upward shift of the Vo2/pressure-volume area relation was similar to that observed with epinephrine and ouabain in our previous studies. CONCLUSIONS: These results suggest that the two positive inotropic drugs exhibit similar mechanoenergetic effects in the normal canine heart despite the different mechanisms of action.
K Hata; Y Goto; S Futaki; T Takasago; A Saeki; T Nishioka; H Suga
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  2     ISSN:  1071-9164     ISO Abbreviation:  J. Card. Fail.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-02-06     Completed Date:  1997-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  203-13     Citation Subset:  IM    
Department of Cardiovascular Dynamics, National Cardiovascular Center, Osaka, Japan.
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MeSH Terms
Cardiotonic Agents / pharmacology*
Heart / drug effects*
Imidazoles / pharmacology*
Myocardial Contraction / drug effects,  physiology
Oxygen Consumption / physiology
Phosphodiesterase Inhibitors / pharmacology*
Pyridones / pharmacology*
Stimulation, Chemical
Ventricular Function, Left / drug effects,  physiology*
Ventricular Pressure / drug effects
Reg. No./Substance:
0/Cardiotonic Agents; 0/Imidazoles; 0/Phosphodiesterase Inhibitors; 0/Pyridones; 73384-60-8/sulmazole; 78415-72-2/Milrinone

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