Document Detail

Effects of mild early life stress on abnormal emotion-related behaviors in 5-HTT knockout mice.
MedLine Citation:
PMID:  17177116     Owner:  NLM     Status:  MEDLINE    
A low-expressing polymorphic variant of the serotonin transporter (5-HTT) gene has been associated with emotional disorders in humans and non-human primates following exposure to early life trauma. 5-HTT gene knockout (KO) mice exhibit increased anxiety- and depression-related behaviors, and provide a model to study interactions between 5-HTT gene variation and early life stress. The present study assessed the effects of postnatal footshock stress on the development of emotion-related behaviors in 5-HTT KO mice. Results showed that 5-HTT KO mice displayed a profile of suppressed exploratory behavior and increased anxiety-like behavior in the light/dark, elevated plus-maze and open field tests, as well as increased depression-related behavior in the forced swim test following repeated exposure to the test. Postnatal exposure to footshock stress did not affect emotion-related behaviors in non-mutant C57BL/6J mice or modify phenotypic abnormalities in 5-HTT KO. Data provide further evidence of emotional abnormalities following genetic disruption of the 5-HTT.
Jenna C Carroll; Janel M Boyce-Rustay; Rachel Millstein; Rebecca Yang; Lisa M Wiedholz; Dennis L Murphy; Andrew Holmes
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Behavior genetics     Volume:  37     ISSN:  0001-8244     ISO Abbreviation:  Behav. Genet.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-17     Completed Date:  2007-07-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0251711     Medline TA:  Behav Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  214-22     Citation Subset:  IM    
Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.
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MeSH Terms
Anxiety Disorders / genetics,  pathology
Behavior, Animal*
Maze Learning
Mice, Knockout
Serotonin Plasma Membrane Transport Proteins / genetics*
Stress, Psychological / genetics*,  metabolism
Reg. No./Substance:
0/Serotonin Plasma Membrane Transport Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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