| Effects of microcin SF608 and microcystin-LR, two cyanotobacterial compounds produced by Microcystis sp., on aquatic organisms. | |
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MedLine Citation:
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PMID: 12203963 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of two cyanobacterial compounds, microcin SF608 and microcystin-LR, were investigated on different physiological parameters of two organisms, the water moss, Vesicularia dubyana, and the waterflea, Daphnia magna. Both compounds are produced by Microcystis species. Microcystin-LR is a potent inhibitor of protein phosphatases 1 and 2A, and microcin SF608 inhibits serine proteases. Other effects of microcystin-LR are well documented in the literature, but adverse effects of microcin SF608 have not been investigated as yet. This study compared the effects of both compounds on detoxication enzymes, microsomal and soluble glutathione-S-transferase (m-, sGST); oxygen stress enzymes, glutathione peroxidase (GP-X), and peroxidase (POD); photosynthetic oxygen production and chlorophyll a:chlorophyll b ratio. mGST was inhibited by both compounds in both organisms, significantly by microcin SF608, possibly indirectly by inhibition of that serine protease transforming the mGST to its active form. The sGST of D. magna was inhibited by microcin SF608, but elevated by microcystin-LR, and elevated by both compounds in V. dubyana. The GP-X in D. magna was not altered by microcin SF608, but elevated parallel to the sGST, whereas the POD in V. dubyana was decreased by both. Photosynthetic oxygen production as well as the chlorophyll a/b ratio showed typical stress reactions, a decrease of oxygen production, and an increase of chlorophyll b, caused both by microcin SF608 and by microcystin-LR. Microcin SF608 was not likely to be detoxified via conjugation to glutathione. The effects of microcin SF608 and microcystin-LR demonstrate that the impact of cyanobacteria on other organisms may not only be directly related to the presently known toxins. |
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Authors:
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Claudia Wiegand; Anja Peuthert; Stephan Pflugmacher; Shmuel Carmeli |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Environmental toxicology Volume: 17 ISSN: 1520-4081 ISO Abbreviation: Environ. Toxicol. Publication Date: 2002 |
Date Detail:
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Created Date: 2002-08-30 Completed Date: 2002-10-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100885357 Medline TA: Environ Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 400-6 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Wiley Periodicals, Inc. |
Affiliation:
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Institute of Biology (Genetics), Humboldt University, Chausseestrasse 117, 10115 Berlin, Germany. cwiegand@igb-berlin.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacteriocins / toxicity* Bryopsida* Daphnia* Enzyme Inhibitors / toxicity* Glutathione Peroxidase / drug effects, pharmacology Microcystins Oxidative Stress Peptides, Cyclic / toxicity* Peroxidase / drug effects, pharmacology Photosynthesis / drug effects Serine Endopeptidases / drug effects, pharmacology Toxicity Tests |
| Chemical | |
Reg. No./Substance:
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0/Bacteriocins; 0/Enzyme Inhibitors; 0/Microcystins; 0/Peptides, Cyclic; 101043-37-2/cyanoginosin LR; 1403-96-9/microcin; EC 1.11.1.7/Peroxidase; EC 1.11.1.9/Glutathione Peroxidase; EC 3.4.21.-/Serine Endopeptidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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