| Effects of metoprolol on rest and exercise cardiac function and plasma catecholamines in chronic congestive heart failure secondary to ischemic or idiopathic cardiomyopathy. | |
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MedLine Citation:
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PMID: 2220583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To define the effects of 2 months of metoprolol therapy on cardiac function, aerobic performance and sympathetic nervous system activity, metoprolol (75 to 100 mg/day) was administered to 10 patients with chronic congestive heart failure (CHF). Metoprolol was discontinued in 2 patients because of worsening CHF. In the remaining 8 patients, peak oxygen uptake increased significantly (14.8 +/- 3.0 to 16.1 +/- 2.5 ml/kg/min, p less than 0.05) as did the oxygen pulse (9.0 +/- 2.2 to 12.6 +/- 1.8 ml/beat, p less than 0.02). Resting heart rate (87 +/- 18 to 62 +/- 9 beats/min, p less than 0.05) and peak exercise heart rate (133 +/- 13 to 105 +/- 30 beats/min, p less than 0.02) were both reduced. Mean resting ejection fraction increased from 0.15 +/- 0.06 to 0.25 +/- 0.11 and peak exercise ejection fraction also tended to increase (0.19 +/- 0.11 to 0.28 +/- 0.15, difference not significant). Both resting plasma norepinephrine (613 +/- 706 to 303 +/- 142 pg/ml, p less than 0.05) and epinephrine (71 +/- 50 to 40 +/- 21 pg/ml, p less than 0.05) were reduced. Circulating lymphocyte beta-adrenergic receptor number was unchanged (1,334 +/- 292 to 1,344 +/- 456 receptors/cell, difference not significant). It is concluded that metoprolol therapy is associated with improvements in rest and exercise ventricular performance and maximal aerobic capacity. These improvements are associated with a decline in resting sympathetic nervous system activity. |
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Authors:
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J W Nemanich; R C Veith; I B Abrass; J R Stratton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of cardiology Volume: 66 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1990 Oct |
Date Detail:
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Created Date: 1990-11-19 Completed Date: 1990-11-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 843-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Seattle Veterans Administration Medical Center, Washington. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiomyopathy, Dilated / complications Catecholamines / blood* Chronic Disease Coronary Disease / complications Epinephrine / blood Exercise Test* Heart / physiopathology* Heart Failure / blood, drug therapy, etiology, physiopathology* Hemodynamics / drug effects Humans Male Metoprolol / therapeutic use* Middle Aged Norepinephrine / blood |
| Grant Support | |
ID/Acronym/Agency:
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AG06581/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 37350-58-6/Metoprolol; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
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