Document Detail

Effects of metoprolol on effort angina during the postprandial state.
MedLine Citation:
PMID:  7379443     Owner:  NLM     Status:  MEDLINE    
To determine whether beta blockers prevent the more rapid onset of effort angina during the postprandial state, metoprolol 100 mg was given before and after an 800-calorie meal in 12 male patients with stable angina and coronary artery disease. Three graded treadmill exercise tests were done daily on 2 days. After an overnight fast the first test on each day was done after a placebo to detect day-to-day variations. The second test was done 90 min after metoprolol or placebo given orally in a double-blind randomized fashion. Immediately thereafter the patients ate their meal and did their third test 30 min later. There was no significant difference between the first test on each day. After placebo the postprandial state was associated with an earlier onset of effort angina (310 and 370 sec, p less than 0.01) and with greater heart rate and systolic blood pressure rises for any work load. After metoprolol, however, there was no significant difference between the pre- and postprandial findings. During the postprandial state metoprolol delayed the onset of angina more than placebo (385 and 310 sec) and positive electrocardiogram (310 and 228 sec) and induced lowering of maximal heart rate (120 and 144 bpm) and systolic blood pressure (157 and 187 mm Hg) (p less than 0.01). Metoprolol slowed the rapid onset of effort agina during the postprandial state.
F Delage; J R Rouleau; J L Labelle; G R Dagenais
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  27     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1980-08-28     Completed Date:  1980-08-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  763-8     Citation Subset:  AIM; IM    
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MeSH Terms
Angina Pectoris / prevention & control*
Blood Pressure / drug effects
Heart Rate / drug effects
Metoprolol / blood,  therapeutic use*
Middle Aged
Oxygen Consumption / drug effects
Physical Exertion*
Propanolamines / therapeutic use*
Time Factors
Reg. No./Substance:
0/Propanolamines; 37350-58-6/Metoprolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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