Document Detail


Effects of metiamide on the human stomach.
MedLine Citation:
PMID:  1104245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The effect of metiamide on gastric acidity in man has been studied. Solutions of hydrochloric acid or glucose were instilled into the stomach and the subsequent rates of gastric secretion and emptying, and the disappearance of acid within the stomach, were measured. 2. Metiamide inhibited the gastric secretory response to the instilled acid and glucose solutions but did not change the overall pattern of emptying of the instilled solutions. 3. During administration of metiamide, there was a net loss of acid from within the gastric lumen. The rate of disappearance of acid from the instilled acid solution was small and not sufficient in magnitude to account for the metiamide-evoked decrease in the concentration of acid secreted in response to pentagastrin. 4. We conclude that metiamide does not inhibit gastric secretion by altering the 'barrier' function of the gastric mucosa.
Authors:
B Thjodleifsson; K G Wormsley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science and molecular medicine     Volume:  49     ISSN:  0301-0538     ISO Abbreviation:  Clin Sci Mol Med     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-02-19     Completed Date:  1976-02-19     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0367540     Medline TA:  Clin Sci Mol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  445-58     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bile Pigments / secretion
Chlorides / secretion
Duodenal Ulcer / physiopathology
Esophagitis / physiopathology
Gastric Juice / secretion*
Gastric Mucosa / drug effects*,  secretion
Humans
Kinetics
Metiamide / pharmacology*
Osmolar Concentration
Pentagastrin / pharmacology
Pepsin A / secretion
Potassium / secretion
Sodium / secretion
Thiourea / analogs & derivatives*
Chemical
Reg. No./Substance:
0/Bile Pigments; 0/Chlorides; 34839-70-8/Metiamide; 5534-95-2/Pentagastrin; 62-56-6/Thiourea; 7440-09-7/Potassium; 7440-23-5/Sodium; EC 3.4.23.1/Pepsin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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