Document Detail

Effects of methyldopa on umbilical and placental artery blood flow velocity waveforms.
MedLine Citation:
PMID:  1407916     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify the effects of methyldopa on umbilical and placental artery Doppler velocity waveforms in mild preeclamptic and chronic hypertensive women with blood pressure below 160/110 mmHg. METHODS: Twenty-two normotensive, 11 untreated mild preeclamptic, 14 treated mild preeclamptic, 29 untreated chronic hypertensive, and 14 treated chronic hypertensive women were studied. Methyldopa was begun if the blood pressure remained higher than 140/90 mmHg after 24 hours of hospitalization. The pulsatility index (PI) was measured on days 0 and 7. RESULTS: Blood pressure decreased significantly with methyldopa in chronic hypertensive women only (P < .05). The PI did not vary in the umbilical artery in the five groups, or in the placental artery in normotensive, untreated preeclamptic, and untreated chronic hypertensive women. The PI decreased significantly in treated preeclamptic and chronic hypertensive women (P < .05). Birth weight was similar in the hypertensive groups. CONCLUSION: Methyldopa decreases placental vascular resistance in mild preeclamptic and chronic hypertensive women.
E Rey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  80     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-11-13     Completed Date:  1992-11-13     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  783-7     Citation Subset:  AIM; IM    
Centre de Recherche, Hôpital Ste-Justine, Montreal, Quebec, Canada.
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MeSH Terms
Arteries / drug effects,  physiopathology
Blood Flow Velocity / drug effects*
Chronic Disease
Hypertension / drug therapy
Methyldopa / pharmacology*,  therapeutic use
Placenta / blood supply*
Pre-Eclampsia / drug therapy
Umbilical Arteries / drug effects,  physiopathology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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