Document Detail

Effects of methyl methacrylate monomer vapors on respiration and circulation in unanesthetized rats.
MedLine Citation:
PMID:  6956729     Owner:  NLM     Status:  MEDLINE    
A study was conducted in which two groups of female rats were exposed to vaporized MMA-m for a period of 20 minutes daily for 21 and 42 days, respectively. Systolic blood pressure, heart rate, respiration, and ECG were monitored for 5 minutes prior to MMA-m exposure and then during a 20-minute exposure to MMA-m. On the twenty-first and forty-second day, respectively, the aforementioned vectors were monitored again. During the first exposure 63% of the experimental animals displayed marked changes in respiration ranging from a modified Cheyne-Stokes type to periods of very shallow breathing followed by deep breathing. Thirty-eight percent showed ECG changes ranging from premature ventricular contractions and altered QRS complexes to markedly depressed T waves. Continued exposure resulted in an initial decrease followed by an increased systolic blood pressure with an increased respiratory and heart rate. At the final testing period all animals showed abnormal respiratory patterns and ECG changes and demonstrated a heart block pattern. In all animals systolic blood pressure increased the longer they were exposed to MMA-m.
L J Blanchet; D C Bowman; H D McReynolds
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of prosthetic dentistry     Volume:  48     ISSN:  0022-3913     ISO Abbreviation:  J Prosthet Dent     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376364     Medline TA:  J Prosthet Dent     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  344-8     Citation Subset:  D; IM    
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MeSH Terms
Blood Circulation / drug effects
Blood Pressure / drug effects*
Heart Rate / drug effects
Methylmethacrylates / pharmacology*
Rats, Inbred Strains
Respiration / drug effects*
Time Factors
Reg. No./Substance:
0/Methylmethacrylates; 80-62-6/Methylmethacrylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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