Document Detail

Effects of metformin plus rosuvastatin on hyperandrogenism in polycystic ovary syndrome patients with hyperlipidemia and impaired glucose tolerance.
MedLine Citation:
PMID:  22522778     Owner:  NLM     Status:  Publisher    
Aim: We aimed to compare the effects of metformin and metformin-rosuvastatin combination therapies on hyperandrogenism in patients with polycystic ovary syndrome (PCOS). Patients and Methods: Thirty-eight PCOS patients with hyperlipidemia and impaired glucose tolerance (IGT), who were followed at Department of Endocrinology and Metabolism out-patient clinic of Cerrahpasa Medical School were included in the study. 20 of the patients had lifestyle changes and metformin (2000 mg/day) therapy (M group) and 18 of the patients had statin (rosuvastatin 10 mg/day) in addition to this therapy (MR group). Total and free testosterone, dehydroepiandrosteron sulphate (DHEAS), follicule stimulating hormone (FSH), luteinizing hormone (LH), estrodiol, fasting glucose, insulin and hs-CRP levels, lipid parameters and Homeostasis Model Assesment Index (HOMA-IR) were evaluated for each patient before and 12 weeks after the treatment. Results: After 12 weeks of treatment body mass index (BMI), insulin and glucose levels, HOMA-IR had similar decreaments in both groups, whereas there was a greater decline of the total and free testosterone levels in MR group (p< 0.001, p= 0.004, respectively). DHEAS levels did not change in M group however significantly decreased in MR group after treatment (p=0.8, p=0.002, respectively). As expected hsCRP, triglyceride, total and LDLcholesterol levels decreased more in MR group. Conclusion: Metformin and rosuvastatin combination therapy could lead to a better reduction on hyperandrogenism and on atherosclerosis-related factors in PCOS, in addition to improving lipid parameters.
O Celik; O Acbay
Related Documents :
7809438 - The effect of nebulized salbutamol therapy on the incidence of postoperative chest infe...
2658918 - Oral prophylaxis with neomycin and erythromycin in colorectal surgery. more proof for e...
7042028 - Clinical trials of the efficacy and duration of antibacterial cover for elective resect...
8085278 - Challenges in comparing treatment outcome from a prospective with that of a retrospecti...
16634738 - Post-thrombotic syndrome, recurrence, and death 10 years after the first episode of ven...
24231228 - Conservative treatment of a proximal full-thickness biceps brachii muscle tear in a spe...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-18
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  -     ISSN:  1720-8386     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Isolation and characterization of melanopsin photoreceptors of Atlantic salmon (Salmo salar).
Next Document:  Allogeneic bone marrow grafts with high levels of CD4(+) CD25(+) FoxP3(+) T cells can lead to engraf...