Document Detail


Effects of metformin plus rosuvastatin on hyperandrogenism in polycystic ovary syndrome patients with hyperlipidemia and impaired glucose tolerance.
MedLine Citation:
PMID:  22522778     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim: We aimed to compare the effects of metformin and metformin-rosuvastatin combination therapies on hyperandrogenism in patients with polycystic ovary syndrome (PCOS). Patients and Methods: Thirty-eight PCOS patients with hyperlipidemia and impaired glucose tolerance (IGT), who were followed at Department of Endocrinology and Metabolism out-patient clinic of Cerrahpasa Medical School were included in the study. 20 of the patients had lifestyle changes and metformin (2000 mg/day) therapy (M group) and 18 of the patients had statin (rosuvastatin 10 mg/day) in addition to this therapy (MR group). Total and free testosterone, dehydroepiandrosteron sulphate (DHEAS), follicule stimulating hormone (FSH), luteinizing hormone (LH), estrodiol, fasting glucose, insulin and hs-CRP levels, lipid parameters and Homeostasis Model Assesment Index (HOMA-IR) were evaluated for each patient before and 12 weeks after the treatment. Results: After 12 weeks of treatment body mass index (BMI), insulin and glucose levels, HOMA-IR had similar decreaments in both groups, whereas there was a greater decline of the total and free testosterone levels in MR group (p< 0.001, p= 0.004, respectively). DHEAS levels did not change in M group however significantly decreased in MR group after treatment (p=0.8, p=0.002, respectively). As expected hsCRP, triglyceride, total and LDLcholesterol levels decreased more in MR group. Conclusion: Metformin and rosuvastatin combination therapy could lead to a better reduction on hyperandrogenism and on atherosclerosis-related factors in PCOS, in addition to improving lipid parameters.
Authors:
O Celik; O Acbay
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-18
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  -     ISSN:  1720-8386     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey.
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