Document Detail

Effects of mesalazine substitution on salicylazosulfapyridine-induced seminal abnormalities in men with ulcerative colitis.
MedLine Citation:
PMID:  2572047     Owner:  NLM     Status:  MEDLINE    
Some semen characteristics of eight male patients with clinically inactive ulcerative colitis were investigated. Semen analysis was carried out twice during salicylazosulfapyridine (SASP) treatment and repeated twice after at least 3 months' treatment with mesalazine. The motility variables all showed significant improvement during mesalazine treatment: the graded motility (p less than 0.05), motility in percentage (p less than 0.01), and the penetration in egg white (p less than 0.05). The semen plasma was analyzed for mesalazine and the metabolite Ac-mesalazine during both regimens. There was no difference in the semen plasma concentration of mesalazine during the two regimens, whereas Ac-mesalazine was significantly higher during mesalazine treatment than during SASP treatment, indicating that other SASP metabolites, most likely sulfapyridine, are the agent causing the abnormal sperm characteristics. We suggest that pure mesalazine preparations are a safer alternative in young men with chronic inflammatory bowel disease.
N Kjaergaard; L A Christensen; J G Lauritsen; S N Rasmussen; S H Hansen
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  24     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-11-20     Completed Date:  1989-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  891-6     Citation Subset:  IM    
Dept. of Obstetrics and Gynecology, Aalborg Hospital, Denmark.
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MeSH Terms
Aminosalicylic Acids / administration & dosage*,  analysis
Colitis, Ulcerative / drug therapy*
Delayed-Action Preparations
Middle Aged
Semen / analysis,  drug effects*
Sperm Motility / drug effects*
Sulfasalazine / adverse effects*,  therapeutic use
Reg. No./Substance:
0/Aminosalicylic Acids; 0/Delayed-Action Preparations; 599-79-1/Sulfasalazine; 89-57-6/Mesalamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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