Document Detail

Effects of menstrual cycle on postoperative analgesic requirements, agitation, incidence of nausea and vomiting after gynecological laparoscopy.
MedLine Citation:
PMID:  15467297     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Several studies have suggested that the menstrual cycle has an impact on postoperative nausea and vomiting (PONV). No previous study has evaluated the effect of the menstrual cycle on the incidence of postoperative agitation and analgesic/antiemetic requirements. METHODS: On the basis of the phase of the menstrual cycle [pre+/-menstrual (Pd 25-6), early follicular phase (Pd 8-12), ovulatory phase (Pd 13-15), and luteal phase (Pd 20-24)], 67 patients enrolled in this blinded, prospective study. Anesthesia was standardized. Fentanyl was given to the patients who had severe pain in the recovery room. The patients who had agitation were given midazolam. When pain intensity was >5 on the Visual Analog Scale, metamizol was administered in the Gynecology Department. A blinded anesthesiologist recorded episodes of PONV in the recovery room, and 2 and 24 h postoperatively. RESULTS: The opioid requirement and the frequency of agitation were similar in each group. Metamizol consumption was highest in the luteal phase (p < 0.05). The follicular and luteal phases were predictors for vomiting at recovery (p < 0.05 and p < 0.001, respectively). At the postoperative 2nd hour, nausea was higher in the follicular phase than in the other phases (p < 0.05) and the luteal phase was a predictor for retching (p < 0.001). At the postoperative 24th hour, nausea was the common symptom in the luteal phase (p < 0.05). The need for ondansetron was highest in the luteal phase (p < 0.01). CONCLUSIONS: In conclusion, we suggest that the scheduling of all surgical procedures according to the menstrual phase may serve to reduce the incidence of PONV and metamizol/ondansetron consumption and hospital costs.
Elif Bengi Sener; Serhat Kocamanoglu; Mehmet Bilge Cetinkaya; Emre Ustun; Emine Bildik; Ayla Tur
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2004-09-30
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  59     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2005  
Date Detail:
Created Date:  2005-01-03     Completed Date:  2005-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  49-53     Citation Subset:  IM    
Copyright Information:
Copyright 2005 S. Karger AG, Basel.
Ondokuzmayis University, Faculty of Medicine, Samsun, Turkey.
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MeSH Terms
Analgesics / administration & dosage
Antiemetics / administration & dosage
Gynecologic Surgical Procedures
Menstrual Cycle*
Pain Measurement
Pain, Postoperative / epidemiology,  etiology,  prevention & control
Postoperative Nausea and Vomiting / epidemiology*,  etiology,  prevention & control*
Turkey / epidemiology
Reg. No./Substance:
0/Analgesics; 0/Antiemetics

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