Document Detail

Effects of memantine on event-related potential, oscillations, and complexity in individuals with and without family histories of alcoholism.
MedLine Citation:
PMID:  23384372     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Enhanced N-methyl-D-aspartate (NMDA) receptor function associated with a positive family history of alcoholism (FHP) has been hypothesized to contribute to the heritable risk for alcoholism. The objective of this study was to evaluate the relationship of alcoholism family history, NMDA receptor function, and cortical information processing by testing acute effects of the NMDA receptor antagonist memantine on event-related potential (ERP).
METHOD: Twenty-two healthy FHP and 20 healthy family history-negative (FHN; no alcoholic relatives) subjects were administered placebo or 40 mg of memantine under double-blind counterbalanced conditions on two separate occasions. Electroencephalogram data were collected from eight channels with eyes open during an auditory oddball discrimination task. We evaluated P3b amplitude, total theta, alpha activity, and fractal dimension from ERP trials.
RESULTS: FHP and FHN subjects did not differ in P3b amplitude. A significant Group × Drug interaction was observed in theta, alpha activity, and fractal dimension at the parietal and occipital sites. FHP individuals exhibited significantly higher fractal dimension and lower theta and alpha activity after placebo relative to FHN subjects. Following memantine administration, theta activity decreased in both groups but more markedly for FHN individuals. Alpha activity decreased for FHN subjects and increased for FHP individuals, whereas the fractal dimension decreased for FHP subjects and increased for FHN subjects after memantine.
CONCLUSIONS: A plausible interpretation of these results is that FHP individuals may have altered NMDA receptor function compared with FHN individuals. These findings provide additional evidence of differences in the regulation of NMDA receptor function between FHP and FHN individuals.
Balaji Narayanan; Michael C Stevens; Rachel E Jiantonio; John H Krystal; Godfrey D Pearlson
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of studies on alcohol and drugs     Volume:  74     ISSN:  1938-4114     ISO Abbreviation:  J Stud Alcohol Drugs     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-06     Completed Date:  2013-07-22     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  101295847     Medline TA:  J Stud Alcohol Drugs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  245-57     Citation Subset:  IM    
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MeSH Terms
Alcoholism / epidemiology,  physiopathology*
Case-Control Studies
Discrimination (Psychology)
Double-Blind Method
Excitatory Amino Acid Antagonists / pharmacology*
Family Health*
Memantine / pharmacology
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors,  metabolism*
Risk Factors
Young Adult
Grant Support
Reg. No./Substance:
0/Excitatory Amino Acid Antagonists; 0/Receptors, N-Methyl-D-Aspartate; W8O17SJF3T/Memantine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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