Document Detail

Effects of melatonin on noncardiogenic pulmonary edema secondary to adnexial ischemia-reperfusion in guinea pig.
MedLine Citation:
PMID:  12011796     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Pulmonary edema has been shown to occur following ischemia-reperfusion injury in a variety of organs and effects of several pharmacological agents on ischemia-reperfusion-induced damage has been investigated previously. However, there are only a few studies in the literature about pulmonary injury following adnexial ischemia-reperfusion. In this study we aimed at investigating pulmonary changes following adnexial ischemia-reperfusion and the effects of melatonin on noncardiogenic pulmonary edema secondary to adnexial ischemia-reperfusion. METHODS: A total of 32 Dunkin-Harley guinea pigs were randomly divided into four groups. In group I, oopherectomy was performed following adnexial torsion of three hours (ischemia). Adnexial torsion of three hours followed by a 3 hours detorsion period (reperfusion) and then oopherectomy was performed in remaining three groups. No therapy was given in group one and two while isotonic saline and melatonin was applied intraperitoneally in groups three and four, respectively. Serum malondialdehyde (MDA) levels of operated ovaries and lungs and polimorphonuclear leucocyte infiltration of lungs were determined. RESULTS: MDA levels in serum, ovary and lungs were higher in detorsion groups (groups II, III) than torsion group (group I) (p<0.01). Melatonin administration significantly decreased the polimorphonuclear leukocytes infiltration of lung parenchime and MDA levels in serum, ovaries and lungs (groups II and IV; groups III and IV; p<0.01, p<0.01). MDA levels and lung tissue PNL infiltration levels of melatonin administered detorsioned group was similar to those levels of only salphingo-oopherectomy performed group (Group I and IV, p>0.05). CONCLUSION: Pathophysiology of ischemia-reperfusion must be considered in the cases of adnexial torsion where detorsion is thought. As an antioxidant, melatonin administration might be helpful in decreasing post-operative morbidity by decreasing reperfusion injury of lungs.
Husnu Celik; Ahmet Ayar; Niyazi Tug; Mehmet Simsek; Ibrahim Ozercan; Gürkan Cikim; Ibrahim Bildirici
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  23     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-15     Completed Date:  2002-09-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  115-8     Citation Subset:  IM    
Firat University, Faculty of Medicine, Department of Obstetrics and Gynecology, Elazig, Turkey.
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MeSH Terms
Adnexal Diseases / complications,  drug therapy
Antioxidants / pharmacology*
Guinea Pigs
Lung / chemistry,  pathology
Malondialdehyde / analysis
Melatonin / pharmacology*
Pulmonary Edema / drug therapy*,  etiology,  pathology
Reperfusion Injury / complications,  drug therapy*,  pathology
Torsion Abnormality
Reg. No./Substance:
0/Antioxidants; 542-78-9/Malondialdehyde; 73-31-4/Melatonin

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