| Effects of melatonin on hypothalamic gamma-aminobutyric acid, aspartic acid, glutamic acid, beta-endorphin and serotonin levels in male mice. | |
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MedLine Citation:
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PMID: 8720689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of melatonin on hypothalamic neurotransmitters in male mice were studied. Exogenous melatonin administered intraperitoneally significantly increased (p < 0.05) hypothalamic concentrations of aspartic acid and gamma-aminobutyric acid by over 29 and 50% respectively. Conversely, hypothalamic beta-endorphin concentration was significantly decreased (p < 0.05) 30 min after melatonin administration with doses between 5- and 100 micrograms/kg. Similarly, melatonin, at a concentration of 100 micrograms/kg, decreased (p < 0.05) the serotonin level in mouse hypothalamus by 46%. Melatonin, however, did not affect the concentration of hypothalamic glutamic acid over a dose range of 0.5-300 micrograms melatonin/kg. Our findings suggested that actions of pineal melatonin in animals such as inhibition on serum corticosterone levels might be mediated by the potentiation of activities of hypothalamic neurons containing gamma-aminobutyric acid and aspartic acid or by the inhibition of the beta-endorphin and serotonin hypothalamic neurons. The neurons containing glutamic acid in the hypothalamus were, however, not influenced by melatonin. Our results are in line with the suggestion that melatonin actions on adrenal corticosterone release or other endocrine secretions may be mediated by way of its actions on hypothalamic neurotransmitter activities. |
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Authors:
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F Xu; J C Li; K C Ma; M Wang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological signals Volume: 4 ISSN: 1016-0922 ISO Abbreviation: Biol. Signals Publication Date: 1995 Jul-Aug |
Date Detail:
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Created Date: 1996-10-08 Completed Date: 1996-10-08 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9210083 Medline TA: Biol Signals Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 225-31 Citation Subset: IM |
Affiliation:
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Chronopharmacology Laboratory, Shenyang Pharmaceutical University, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aspartic Acid / metabolism Dose-Response Relationship, Drug Glutamic Acid / metabolism Hypothalamus / drug effects, metabolism* Kinetics Male Melatonin / pharmacology* Mice Mice, Inbred Strains Neurotransmitter Agents / metabolism* Reference Values Serotonin / metabolism* beta-Endorphin / metabolism* gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Neurotransmitter Agents; 50-67-9/Serotonin; 56-12-2/gamma-Aminobutyric Acid; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid; 60617-12-1/beta-Endorphin; 73-31-4/Melatonin |
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