| Effects of melatonin and acetylsalicylic acid against hepatic oxidative stress after bile duct ligation in rat. | |
| | |
MedLine Citation:
|
PMID: 19009911 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this study was to assess the effect of melatonin and acetylsalicylic acid (ASA) on hepatic damage induced by bile duct ligation (BDL). MATERIAL AND METHODS: Male Sprague-Dawley rats were subjected to either sham operation or common BDL before treatment with ASA, melatonin or vehicle. Hepatic superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) enzyme activities and reduced glutathione (GSH), malondialdehyde (MDA) and nitric oxide (NO) levels were evaluated. RESULTS: Our results have indicated that BDL caused a significant increase in lipid peroxidation whereas a statistically insignificant decrease in GSH level and some of the antioxidant enzyme activities. Both MEL and ASA administrations, either separately or together, decreased MDA whereas co-administration of MEL with ASA increased GSH levels in BDL rats. CONCLUSIONS: CAT activity and MEL level decreased in the liver tissues of rats with BDL after administration of either melatonin alone or with ASA. However, melatonin and ASA administration increases liver tissue GSH levels in BDL ligated rats |
| | |
Authors:
|
M H Emre; A Polat; M Eşrefoğlu; A B Karabulut; M Gül |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta physiologica Hungarica Volume: 95 ISSN: 0231-424X ISO Abbreviation: Acta Physiol Hung Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-11-17 Completed Date: 2008-12-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8309201 Medline TA: Acta Physiol Hung Country: Hungary |
Other Details:
|
Languages: eng Pagination: 349-63 Citation Subset: IM |
Affiliation:
|
Department of Physiology, Inonu University, Medical School, 44280 Malatya, Turkey. hemre@inonu.edu.tr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anti-Inflammatory Agents, Non-Steroidal / pharmacology Antioxidants / pharmacology Aspirin / pharmacology* Catalase / metabolism Cholestasis, Extrahepatic / drug therapy*, metabolism*, pathology Drug Therapy, Combination Glutathione / metabolism Glutathione Peroxidase / metabolism Ligation Liver / drug effects*, metabolism, pathology Male Melatonin / pharmacology* Nitric Oxide / metabolism Oxidative Stress / drug effects* Rats Rats, Sprague-Dawley Superoxide Dismutase / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antioxidants; 10102-43-9/Nitric Oxide; 50-78-2/Aspirin; 70-18-8/Glutathione; 73-31-4/Melatonin; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Endurance training attenuates the oxidative stress due to acute exhaustive exercise in rat liver.
Next Document: Treadmill running and swimming imposes distinct cardiovascular physiological adaptations in the rat:...