Document Detail

Effects of medroxyprogesterone acetate on subjective arousal, arousal to erotic stimulation, and nocturnal penile tumescence in male sex offenders.
MedLine Citation:
PMID:  3741089     Owner:  NLM     Status:  MEDLINE    
Three chronic pedophiliac sex offenders were treated individually with medroxyprogesterone acetate (MPA) over a minimum of 3 months. Genital and subjective response to erotic stimulation, nocturnal penile tumescence, self-reporting of sexual urges, and testosterone levels were recorded repeatedly throughout the study. A single-subject reversal design was used and medication was administered through a double-blind procedure. The results showed that self-report of arousal outside of a laboratory setting was unreliable as a measure of the drug effect. In a laboratory setting, however, there appeared to be a significant reduction in the report of arousal to erotic stimuli while genital arousal decreased only slightly. Reversal of these responses occurred in only one subject during a final placebo phase. Nocturnal penile tumescence was significantly decreased during MPA administration and appeared to be related to decreases in total testosterone.
J P Wincze; S Bansal; M Malamud
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Publication Detail:
Type:  Case Reports; Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Archives of sexual behavior     Volume:  15     ISSN:  0004-0002     ISO Abbreviation:  Arch Sex Behav     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1273516     Medline TA:  Arch Sex Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  293-305     Citation Subset:  IM    
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MeSH Terms
Arousal / drug effects
Double-Blind Method
Libido / drug effects
Medroxyprogesterone / therapeutic use*
Middle Aged
Paraphilias / drug therapy*
Pedophilia / blood,  drug therapy*
Penile Erection / drug effects
Testosterone / blood
Reg. No./Substance:
520-85-4/Medroxyprogesterone; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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