Document Detail


Effects of medical adhesives in prevention of complications after endoscopic submucosal dissection.
MedLine Citation:
PMID:  23674879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To evaluate the use of medical adhesive spray in endoscopic submucosal dissection (ESD).
METHODS: Patients who underwent ESD between January 2009 and June 2012 (n = 173) were enrolled in the prospective randomized study. Two patients undergoing surgery due to severe intraoperative hemorrhage and failed hemostasis were excluded, and the remaining 171 patients were randomly divided into two groups: group A (medical adhesive group, n = 89) and group B (control group, n = 82). In group A, a medical adhesive spray was evenly applied after routine electrocoagulation and hemostasis using hemostatic clip after ESD. Patients in group B only treated with routine wound management. Intraoperative and postoperative data were collected and compared.
RESULTS: In all 171 patients, ESD was successfully completed. There was no significant difference in the average treatment time between groups A and B (59.4 min vs 55.0 min, respectively). The average length of hospital stay was significantly different between group A and B (8.89 d vs 9.90 d, respectively). The incidence of intraoperative perforation was 10.1% in group A and 9.8% in group B, and was not significantly different between the two groups. In all cases, perforations were successfully managed endoscopically and with conservative treatment. The incidence of postoperative delayed bleeding in group A was significantly lower than that in group B (0.00% vs 4.88%, respectively).
CONCLUSION: ESD is an effective minimally invasive treatment for gastrointestinal precancerous lesions or early-stage gastrointestinal cancer. Medical adhesive spray is effective in preventing delayed bleeding after ESD, and can thus reduce the average length of hospital stay.
Authors:
Yi Zhang; Ying Chen; Chun-Ying Qu; Min Zhou; Qian-Wen Ni; Lei-Ming Xu
Related Documents :
23006969 - Hyperreflective dots: a new spectral-domain optical coherence tomography entity for fol...
24139979 - Influence of the false lumen status on short- and long-term clinical outcomes in patien...
22952099 - Immune thrombocytopenic purpura in adults in the last 10 years: single-centre experience.
24027409 - Pattern and survival of biliary atresia patients; experience in southern nigeria.
24909069 - Similarities and differences in the clinical features between cardia varices and esopha...
24204739 - Continuous versus conventional infusion of amphotericin b deoxycholate: a meta-analysis.
22594679 - Treatment options for alopecia: an update, looking to the future.
20578869 - Chin cup effects using two different force magnitudes in the management of class iii ma...
3901679 - Ultrasonography of the undescended testis.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  19     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-15     Completed Date:  2014-01-03     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  2704-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aerosols
Aged
Aged, 80 and over
Chi-Square Distribution
China
Dissection / adverse effects*
Endoscopy / adverse effects*
Female
Hemostasis, Endoscopic*
Humans
Length of Stay
Male
Middle Aged
Postoperative Hemorrhage / etiology,  prevention & control*
Prospective Studies
Time Factors
Tissue Adhesives / administration & dosage*
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Aerosols; 0/Tissue Adhesives
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Increased expression of DLX2 correlates with advanced stage of gastric adenocarcinoma.
Next Document:  Difference in DRB1* gene polymorphisms between Han and Uyghur ulcerative colitis patients in China.