Document Detail

Effects of mechanosensitive ion channels on ventricular electrophysiology: experimental and theoretical models.
MedLine Citation:
PMID:  16407474     Owner:  NLM     Status:  MEDLINE    
The heart is an electrically driven mechanical pump, somewhat like an electric motor. Interestingly, like an electric motor in 'dynamo mode', the heart can also convert mechanical stimuli into electrical signals. This feedback from cardiac mechanics to electrical activity involves mechanosensitive ion channels, whose properties and pathophysiological relevance are reviewed in the context of experimental and theoretical modelling of ventricular beat-by-beat electromechanical function.
Peter Kohl; Christian Bollensdorff; Alan Garny
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-01-11
Journal Detail:
Title:  Experimental physiology     Volume:  91     ISSN:  0958-0670     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-13     Completed Date:  2006-05-04     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  307-21     Citation Subset:  IM    
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MeSH Terms
Arrhythmias, Cardiac / physiopathology
Heart / physiology*,  physiopathology
Heart Conduction System
Ion Channels / physiology*
Mechanoreceptors / physiology*
Mechanotransduction, Cellular*
Membrane Potentials
Models, Cardiovascular*
Physical Stimulation
Research / economics
Research Design
Ventricular Function
Grant Support
G0400145//Medical Research Council
Reg. No./Substance:
0/Ion Channels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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