| Effects and mechanisms of anal electrical stimulation on anorectal compliance and tone in dogs. | |
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MedLine Citation:
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PMID: 16826335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: This study was designed to investigate the changes in rectal compliance and tone during anal electric stimulation and the involvement of the alpha-adrenergic pathway in conscious dogs. METHODS: Eight healthy dogs were studied in five randomized sessions. Anal sphincter pressure was quantified by using the area under the contractile curve. Rectal compliance and tone were measured in a pressure-controlled phasic and isobaric distention by using an electronic barostat. Anal electric stimulation was performed via a pair of ring electrodes attached to the catheter. RESULTS: The electric stimulation-induced increase in sphincter pressure was lowered by the presence of an alpha(1)-adrenergic receptor antagonist, prazosin (18.6 +/- 7.4 vs. 45.4 +/- 9.7, P < 0.05), or alpha(2)-adrenergic receptor antagonist, yohimbine (10.2 +/- 8.2 vs. 38.3 +/- 7.6, P < 0.05), compared with the control. The threshold volume in rectoanal inhibitory reflex during electric stimulation was significantly higher than during baseline (27.5 +/- 0.9 vs. 22.5 +/- 1.9 ml, P < 0.05). There were no significant differences between the percentage drops in sphincter pressure with and without stimulation at a rectal distention level of 45 ml of air. Anal electric stimulation significantly increased rectal compliance reflected as reduced P(1/2) (11.1 +/- 1.5 vs. 16.7 +/- 1.1, P = 0.027) and reduced kappa (11.6 +/- 2.5 vs. 20.5 +/- 2.6, P = 0.0095), compared with the control session, but did not significantly alter rectal tone. CONCLUSIONS: Anal electric stimulation increases anal sphincter pressure, mediated at least partially by the alpha-adrenergic pathway. It also increases rectal compliance but does not alter rectal anal inhibitory reflexes. |
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Authors:
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Yuqiang Nie; J D Z Chen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Diseases of the colon and rectum Volume: 49 ISSN: 0012-3706 ISO Abbreviation: Dis. Colon Rectum Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-14 Completed Date: 2006-11-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372764 Medline TA: Dis Colon Rectum Country: United States |
Other Details:
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Languages: eng Pagination: 1414-21 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX 77555-0632, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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pharmacology Anal Canal / drug effects, innervation, physiology* Animals Compliance Defecation / physiology Dogs Electric Stimulation Female Prazosin / pharmacology Pressure Receptors, Adrenergic, alpha-1 / antagonists & inhibitors Receptors, Adrenergic, alpha-2 / antagonists & inhibitors Rectum / drug effects, innervation, physiology* Reflex / drug effects Yohimbine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Receptors, Adrenergic, alpha-1; 0/Receptors, Adrenergic, alpha-2; 146-48-5/Yohimbine; 19216-56-9/Prazosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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