Document Detail


Effects of mebendazole, albendazole, and praziquantel on alkaline phosphatase, acid phosphatase, and adenosine triphosphatase of Echinococcus granulosus cysts harbored in mice.
MedLine Citation:
PMID:  1302436     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mice infected with protoscoleces of Echinococcus granulosus for 12-14 months were treated ig with mebendazole (Meb) 25-50 mg.kg-1 x d-1 for 7-14 d, albendazole (Alb) 200 mg.kg-1 x d-1, cr praziquantel (Pra) 500 mg.kg-1 x d-1 for 14 d. The mice were killed 24 h after the last medication, and acid phosphatase (ACP), alkaline phosphatase (AKP), and adenosine triphosphatase (ATPase) including (Na, K, Mg)-ATPase, (Na, K)-ATPase, and (Mg)-ATPase were determined and compared with those of untreated control group. The results showed that ACP activities of cyst wall in treated groups were lower than the control group. Whereas AKP activity of cyst wall in Pra group increased markedly, this is not the case in Meb and Alb groups. Three ATPase activities of cyst wall were inhibited in both Meb and Alb groups, Meb being more potent. No apparent changes in the ATPase activities were seen in Pra group.
Authors:
J J Feng; S H Xiao; H F Guo; L Ren; P Y Jiao; M Y Yao; J J Chai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zhongguo yao li xue bao = Acta pharmacologica Sinica     Volume:  13     ISSN:  0253-9756     ISO Abbreviation:  Zhongguo Yao Li Xue Bao     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-06-09     Completed Date:  1993-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100330     Medline TA:  Zhongguo Yao Li Xue Bao     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  497-501     Citation Subset:  IM    
Affiliation:
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai.
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MeSH Terms
Descriptor/Qualifier:
Acid Phosphatase / metabolism*
Adenosine Triphosphatases / metabolism*
Albendazole / pharmacology,  therapeutic use
Alkaline Phosphatase / metabolism*
Animals
Echinococcosis / drug therapy,  enzymology*
Echinococcus
Female
Mebendazole / pharmacology*,  therapeutic use
Mice
Praziquantel / pharmacology,  therapeutic use
Chemical
Reg. No./Substance:
31431-39-7/Mebendazole; 54965-21-8/Albendazole; 55268-74-1/Praziquantel; EC 3.1.3.1/Alkaline Phosphatase; EC 3.1.3.2/Acid Phosphatase; EC 3.6.1.-/Adenosine Triphosphatases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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