| Effects of a meal and bisacodyl on colonic motility in healthy volunteers and patients with slow-transit constipation. | |
| | |
MedLine Citation:
|
PMID: 12870774 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In the present study, the gastrocolonic response after ingestion of a standardized liquid meal and the response to a local chemical stimulus were investigated in 10 healthy volunteers and 10 patients with slow-transit constipation (as determined by marker studies). Colonic pressures were recorded while fasting, after ingestion of a standardized meal and after intracolonic bisacodyl infusion, using a 12-channel water-perfused catheter. Pressure waves propagating over at least 20 cm (HAPPW) were identified visually and automated analysis was carried out on remaining segmental motility. Increases of motility after a meal and bisacodyl were seen in healthy subjects, whereas patients did not show these responses. The time until occurrence of the first HAPPW after bisacodyl infusion tended to be prolonged (4.3 +/- 1.4 vs 36.1 +/- 15.3; P = 0.053) and the number of HAPPWs in the first 30 min. after infusion was lower compared to healthy subjects (2.1 +/- 0.2 vs 5.4 +/- 0.3; P < 0.01). The percentage of HAPPWs that were experienced as urge or cramp was significantly lower in constipated patients (53 +/- 3% vs 95 +/- 1%; P < 0.005). In conclusion, this study shows that in patients with slow-transit constipation, the colonic motor response to a meal and to bisacodyl, as well as the perception of bisacodyl-induced propagated pressure waves is decreased. |
| | |
Authors:
|
A M P De Schryver; M Samsom; A I P M Smout |
Related Documents
:
|
17562174 - Spontaneous and bolus-induced motility in the chronically obstructed guinea-pig small i... 18625134 - Biomechanics of the esophagogastric junction in gastroesophageal reflux disease. 12195184 - Combined radiologic and manometric study of rectal filling sensation. 1735344 - Sphincter of oddi dysfunction and unexplained abdominal pain: clinical and manometric s... 8111574 - Nasal cpap: an objective evaluation of patient compliance. 12578874 - Combined ventricular systolic and arterial stiffening in patients with heart failure an... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Digestive diseases and sciences Volume: 48 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2003 Jul |
Date Detail:
|
Created Date: 2003-07-21 Completed Date: 2003-09-09 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 1206-12 Citation Subset: AIM; IM |
Affiliation:
|
The Gastrointestinal Research Unit, Department of Gastroenterology and Surgery, University Medical Center Utrecht, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Bisacodyl / pharmacology* Cathartics / pharmacology* Colon / drug effects*, physiology, physiopathology Constipation / physiopathology* Eating / physiology* Evoked Potentials / drug effects, physiology Female Gastrointestinal Transit / drug effects*, physiology Humans Male Pressure Sensation / drug effects, physiology, radiation effects |
| Chemical | |
Reg. No./Substance:
|
0/Cathartics; 603-50-9/Bisacodyl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of straining during defecation in three positions: results and implications for human hea...
Next Document: Dietary restrictions during ambulatory monitoring of duodenogastroesophageal reflux.