| Effects of maximal exercise stress on left ventricular function in patients with coronary artery disease using first pass radionuclide angiocardiography: a rapid, noninvasive technique for determining ejection fraction and segmental wall motion. | |
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MedLine Citation:
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PMID: 758125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiographically determined changes in segmental wall motion (SWM) and ejection fraction (EF) are sensitive indices of left ventricular (LV) function. To compare the effects of exercise on LV function, first pass radionuclide angiocardiography was used before and during maximal upright bicycle stress in patients with nonsignificantly stenosed coronary arteries, and in those with greater than 75% stenosis. Gamma camera acquisitions were made in the 30 degree RAO projection using a 20 mCi I.V. bolus of 99mTc-pertechnetate. In the control group (seven normals, one nonsignificant (CAD) the EF significantly increased between rest and exercise (0.65 +/- 0.03 to 0.81 +/- 0.03 (mean +/- SEM), p less than 0.005). In this group SWM measured over the two anterior and two inferoposterior segments uniformly increased. In the 11 patients with a history of angina and significant coronary artery obstruction, the EF did not change in three and significantly decreased in the remaining eight (0.57 +/- 0.04 to 0.45 +/- 0.03, p less than 0.005). In all 11 patients SWM either decreased or did not increase in the areas supplied by the significantly stenosed coronary arteries. Upright maximal stress angiocardiography appears to be well-suited for diagnosing ischemic heart disease and localizing the area of ischemic dysfunction. |
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Authors:
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J A Jengo; V Oren; R Conant; M Brizendine; T Nelson; J M Uszler; I Mena |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Circulation Volume: 59 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1979 Jan |
Date Detail:
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Created Date: 1979-01-26 Completed Date: 1979-01-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 60-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Coronary Disease / physiopathology, radionuclide imaging* Evaluation Studies as Topic Heart / physiopathology* Humans Middle Aged Myocardial Contraction* Physical Exertion* Technetium / diagnostic use |
| Chemical | |
Reg. No./Substance:
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7440-26-8/Technetium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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