Document Detail

Effects on the maternofetal unit of the rabbit model after substitution of the amniotic fluid with perfluorocarbons.
MedLine Citation:
PMID:  16113554     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Exchanging amniotic fluid (AF) with perfluorocarbon (PFC) may serve as a medium for fetoscopic surgery. This study evaluates the distribution and physiologic effects of intraamniotic PFC as a medium for fetoscopy. METHODS: Fetuses of 17 pregnant rabbits underwent either exchange of the AF with PFC, electrolyte solution (ES), or control. The quality of vision during fetoscopy was assessed in AF and PFC. After 6 h, we determined the distribution of PFC in the maternofetal unit. RESULTS: Quality of vision during fetoscopy was better in PFC than with AF. There was no difference in fetal survival between the study groups. PFC was demonstrated on X-ray in the pharynx of 4 fetuses, and the esophagus in 1. CONCLUSIONS: PFC provided an ideal medium for fetoscopy without fetal compromise.
Oliver J Muensterer; Verena J Klis; Holger Till; Dietrich von Schweinitz; Georg Simbruner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  20     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    2005 Sep-Oct
Date Detail:
Created Date:  2005-08-22     Completed Date:  2005-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  359-65     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 S. Karger AG, Basel.
Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University of Munich, Munich, Germany.
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MeSH Terms
Amniotic Fluid*
Electrolytes / pharmacology
Esophagus / radiography
Fetoscopy / methods*,  mortality
Fluorocarbons / pharmacology*
Heart Rate, Fetal
Lung / radiography
Models, Animal
Pharynx / radiography
Reg. No./Substance:
0/Electrolytes; 0/Fluorocarbons

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