Document Detail


Effects of maternal undernutrition on the hypothalamic-pituitary-gonadal axis function in female sheep offspring.
MedLine Citation:
PMID:  19642222     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A study was conducted to evaluate the effects of maternal undernutrition on the hypothalamic-pituitary-gonadal axis in female sheep offspring. Pregnant ewes were fed to 100% throughout pregnancy (Control) or to 50% from 0 to 30 (R1) or from 31 to 100 days of gestation (R2). Female lambs were selected and fed to appetite throughout the study. At 2, 5.5 and 10 months of age a GnRH challenge was conducted. At the age of 10 months lambs were synchronized and blood samples were collected at 3 h intervals for 72 h following sponge removal. At slaughter (10 months) ovaries were removed and examined macroscopically. Maternal undernutrition did not affect the time of the onset of puberty, defined as the first increase in plasma progesterone concentrations >or=1 ng/ml. The magnitude of the pre-ovulatory gonadotrophin surge and the time to surge were unaffected by treatment. The LH and FSH response to GnRH challenge did not differ between groups at 2 and 5.5 months but at 10 months of age a higher (p < 0.05) FSH response was found in R1 group. Although the total number of visible follicles and corpora lutea did not differ between groups, a significant higher (p < 0.05) number of small (2-3 mm diameter) follicles in R1 group and a significant lower number (p < 0.05) of corpora lutea with diameter 8-11 mm and not even one with diameter >12 mm were detected in the ovaries of R2 lambs. In conclusion, maternal undernutrition during the first month of pregnancy resulted in increased pituitary sensitivity to GnRH and increased number of small follicles in the ovary, while during mid to late gestation resulted in a reduction of large corpora lutea in female offspring.
Authors:
B Kotsampasi; S Chadio; G Papadomichelakis; S Deligeorgis; D Kalogiannis; I Menegatos; G Zervas
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproduction in domestic animals = Zuchthygiene     Volume:  44     ISSN:  1439-0531     ISO Abbreviation:  Reprod. Domest. Anim.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-29     Completed Date:  2009-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9015668     Medline TA:  Reprod Domest Anim     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  677-84     Citation Subset:  IM    
Affiliation:
Laboratory of Anatomy and Physiology of Domestic Animals, Department of Animal Science, Agricultural University of Athens, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Corpus Luteum / anatomy & histology
Female
Follicle Stimulating Hormone / blood
Gestational Age
Gonadotropin-Releasing Hormone / diagnostic use,  pharmacology
Hypothalamus / physiology*
Luteinizing Hormone / blood
Malnutrition / veterinary*
Ovarian Follicle / anatomy & histology
Ovary / anatomy & histology,  physiology*
Pituitary Gland / drug effects,  physiology*
Pregnancy
Prenatal Exposure Delayed Effects / veterinary*
Sexual Maturation
Sheep*
Chemical
Reg. No./Substance:
33515-09-2/Gonadotropin-Releasing Hormone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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