Document Detail

Effects of maternal subclinical hypothyroidism on obstetrical outcomes during early pregnancy.
MedLine Citation:
PMID:  21642766     Owner:  NLM     Status:  Publisher    
Background Maternal hypothyroidism (OH and SCH) during early pregnancy is suspected to associate with adverse obstetrical outcomes. Aim The aim of the present study was to investigate whether maternal subclinical hypothyroidism during the early stage of pregnancy increase obstetrical complications and whether treatment results in an improvement in these outcomes. Subjects and Methods A total of 756 women in the first trimester (≤12 weeks) of pregnancy were enrolled through ten hospitals in Shenyang from 2007 to 2009. All participants underwent thyroid function testing in early pregnancy and their obstetrical outcomes were studied following delivery. Results The incidence of spontaneous abortions in the subclinical hypothyroidism group was higher than the normal TSH group's (15.48% vs 8.86%, p=0.03). No significant association was observed between subclinical hypothyroidism and other obstetrical complications including gestational hypertension, premature delivery, anemia, postpartum hemorrhage, low neonatal Apgar scores and low birth weight. Although levothyroxine (L-T4) treatment decreased the incidence of spontaneous abortions in women with subclinical hypothyroidism, it was not statistically significant when compared to women who did not receive treatment in the SCH group. None of the 28 women who received L-T4 treatment had premature delivery, low birth weight, hemorrhage and low Apgar score. Conclusions The incidence of spontaneous abortion in pregnant women with subclinical hypothyroidism increased in early pregnancy.
S Wang; W P Teng; J X Li; W W Wang; Z Y Shan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-31
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  -     ISSN:  1720-8386     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-6-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Endocrine, The First Hospital of China Medical University. Shenyang, PR.China,110001.
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