| Effects of maternal stress during different gestational periods on the serotonergic system in adult rat offspring. | |
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MedLine Citation:
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PMID: 3252275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnant Sprague-Dawley rats were exposed to mild stress treatments during different gestational periods and the offspring were investigated at 60 days of age. In the first study, stress from embryonic day (ED) 11 to ED 20 produced effects similar to those reported following stress throughout pregnancy; increased numbers of 5-HT2 binding sites in cerebral cortex and a reduced intensity of the behavioral syndrome produced by injections of the 5-HT agonist 5-methoxy-N,N-dimethyltryptamine (5-MeODMT). In the second study, stress from ED 3 to ED 14 had no significant effect on the intensity of the 5-MeODMT-elicited 5-HT syndrome while stress from ED 15 to ED 20 had a similar effect as stress throughout pregnancy. These data provide evidence that the critical period for prenatal stress-induced changes in brain 5-HT neurons is between ED 15 and birth. This suggests that the mechanism involves an interaction with developmental events occurring within this time span such as the growth of nerve axons and the formation of synaptic contacts. Our findings also provide further evidence that stress during the final trimester of pregnancy may have serious adverse effects on fetal brain development. |
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Authors:
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D A Peters |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 31 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-08-01 Completed Date: 1989-08-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 839-43 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Health Sciences, University of Ottawa, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / drug effects Cerebral Cortex / analysis Female Gestational Age* Male Methoxydimethyltryptamines / pharmacology Pregnancy Prenatal Exposure Delayed Effects* Rats Rats, Inbred Strains Receptors, Serotonin / analysis*, metabolism, physiology Serotonin / physiology* Sex Factors Spiperone / metabolism Stress, Physiological / physiopathology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Methoxydimethyltryptamines; 0/Receptors, Serotonin; 50-67-9/Serotonin; 749-02-0/Spiperone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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