Document Detail

Effects of maternal smoking during pregnancy on offspring blood pressure in late adolescence.
MedLine Citation:
PMID:  22388229     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Previous studies suggest that maternal smoking during pregnancy is associated with elevated offspring blood pressure during childhood. We aimed to investigate whether this association remained in late adolescence and, if so, whether it could be attributed to an intrauterine effect or to familial confounding.
METHODS: We used a national cohort of 87,223 young Swedish men born between 1983 and 1988 with information on both maternal smoking during pregnancy and blood pressure at military conscription. The cohort included 780 full brothers discordant for maternal smoking. Generalized estimation equations were used to estimate regression coefficients (β) with 95% confidence intervals (95% CIs).
RESULTS: We found a small but significant increase in both SBP and DBP for young men whose mothers had been daily smokers during pregnancy compared with sons of nonsmoking mothers: 0.26 (95% CI 0.09 to 0.44) and 0.45 mmHg (95% CI 0.31 to 0.59) for SBP and DBP, respectively. In a within-sibling analysis comparing full brothers discordant for maternal smoking exposure, point estimates were similar but not statistically significant: 0.85 (95% CI -0.19 to 1.90) for DBP and 0.81 (-0.56 to 2.19) for SBP.
CONCLUSION: Maternal smoking during pregnancy is associated with a small but statistically significant increase in offspring blood pressure in late adolescence. Because the association does not appear to be explained by familial confounding, our results support an intrauterine effect of prenatal smoking exposure on blood pressure in late adolescence.
Lovisa Högberg; Sven Cnattingius; Cecilia Lundholm; Brian M D'Onofrio; Niklas Långström; Anastasia N Iliadou
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  30     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-16     Completed Date:  2012-07-16     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  693-9     Citation Subset:  IM    
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MeSH Terms
Birth Weight
Blood Pressure / drug effects*,  physiology
Cohort Studies
Gestational Age
Hypertension / epidemiology,  etiology*,  physiopathology
Maternal Exposure / adverse effects*
Maternal-Fetal Exchange / drug effects*
Pregnancy Outcome
Prenatal Exposure Delayed Effects / epidemiology,  etiology*
Smoking / adverse effects*
Sweden / epidemiology
Young Adult
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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