Document Detail


Effects of maternal separation on baseline sleep and cold stress-induced sleep rebound in adult Wistar rats.
MedLine Citation:
PMID:  15532209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STUDY OBJECTIVES: To evaluate the influence of early life environments on basal and cold stress-induced sleep patterns in rats. DESIGN: The design was a 3 (Groups [control, early handling, maternal separation]) x 2 (Situations [basal, poststress]) x 11 (Time-blocks) factorial design. From postnatal days 2 to 14, whole litters were either submitted to early handling (15 minutes per day away from the mother) or maternal separation (180 minutes per day away from the mother). At 75 to 90 days of age, sleep was recorded for 22 hours (beginning at 9:00 AM) before and after 1 hour of cold stress (4 degrees C). SUBJECTS: Wistar male rats (n = 7-10 animals per group). MEASUREMENTS AND RESULTS: Sleep was analyzed in blocks of 2 hours, in 30-second epochs, separately in the daytime and nighttime sleep recordings. Maternally separated rats exhibited more paradoxical sleep at baseline, compared to both control and early-handled rats. In the first 2 hours following the end of cold stress, all groups showed a decrease in paradoxical sleep, whereas slow-wave sleep was reduced only in the control group. The highest corticosterone plasma concentration was observed immediately after stress. Sleep rebound after stress was equally manifested in all groups in the dark part of the light-dark cycle. CONCLUSIONS: Maternal separation during early infancy resulted in permanent changes of the sleep architecture reflected by augmented time spent in paradoxical sleep. Although these findings were not expected in light of the literature, they emphasize the importance of the early familiar environment on future behavior of rats.
Authors:
Paula Ayako Tiba; Sergio Tufik; Deborah Suchecki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Sleep     Volume:  27     ISSN:  0161-8105     ISO Abbreviation:  Sleep     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-11-09     Completed Date:  2005-02-08     Revised Date:  2009-01-29    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1146-53     Citation Subset:  IM    
Affiliation:
Department of Psychobiology, Universidade Federal de São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / physiology*
Cold Temperature*
Corticosterone / blood
Electrodes, Implanted
Habituation, Psychophysiologic
Mothers*
Rats
Rats, Wistar
Sleep / physiology*
Stress, Physiological / psychology*
Wakefulness*
Chemical
Reg. No./Substance:
50-22-6/Corticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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