Document Detail

Effects of maternal preeclampsia on brain-stem auditory evoked response in very low birth weight infants.
MedLine Citation:
PMID:  7608796     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Because stress in utero may enhance neuromotor maturation, we hypothesized that infants born to mothers with preeclampsia would have a shorter absolute latency V and interpeak latency I-V period (brain-stem conduction time) of brain-stem auditory evoked response (BAER) than infants born to normotensive mothers. STUDY DESIGN: A retrospective cohort study was performed to assess the effects of maternal preeclampsia on BAER of very low birth weight infants. The cohort consisted of 24 infants with a birth weight less than 1251 gm born to mothers with preeclampsia, and 48 infants born to normotensive mothers, matched for birth date within 2 months, gestational age, and chronologic age at the time of the BAER test. The BAER test was completed before discharge, with the infant in a quiet state and the use of a 30 dB stimulus. RESULTS: The mean latencies of wave V were shortened bilaterally (left 8.60 +/- 0.6 msec vs 9.02 +/- 0.6 msec, p < 0.008; right 8.61 +/- 0.6 msec vs 8.96 +/- 0.6 msec, p < 0.033, and the interpeak latency of I-V was significantly shortened compared with the control subjects on the left (left 4.91 +/- 0.5 msec vs 5.38 +/- 0.6 msec, p < 0.003; right 5.17 +/- 0.5 msec vs 5.37 +/- 0.6 msec, not significant). CONCLUSION: These results suggest that the intrauterine stress of maternal preeclampsia accelerates the maturation of the auditory nerve and brain-stem auditory pathway in very low birth weight infants.
C R Kim; B R Vohr; W Oh
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  127     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-08-11     Completed Date:  1995-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  123-7     Citation Subset:  AIM; IM    
Hanyang University School of Medicine, Seoul Korea.
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MeSH Terms
Auditory Pathways / physiology
Cohort Studies
Embryonic and Fetal Development
Evoked Potentials, Auditory, Brain Stem*
Fetal Growth Retardation / etiology*
Fetal Organ Maturity
Infant, Low Birth Weight*
Infant, Newborn
Maternal Welfare*
Maternal-Fetal Exchange
Pre-Eclampsia / complications*
Retrospective Studies
Vestibulocochlear Nerve / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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