Document Detail

Effects of maternal and placental inflammation on retinopathy of prematurity.
MedLine Citation:
PMID:  21455777     Owner:  NLM     Status:  Publisher    
PURPOSE: To identify maternal and placental risk factors for the occurrence and progression of retinopathy of prematurity (ROP). METHODS: This was a retrospective cohort study. The study cohort consisted of 246 infants with gestational age ≤32 weeks, with histologic examinations of their placentas. Medical records of eligible preterm infants were retrospectively reviewed. A regression model was constructed with control for known or potential factors associated with ROP. Occurrences of ROP, severe ROP (≥stage 3), and clinically significant ROP requiring laser treatment were assessed. RESULTS: ROP was diagnosed in 82 of 246 infants (33.3%), including 49 with mild ROP and 33 with severe ROP. Laser treatment was performed on 27 infants (11%: 27/246). Multivariate regression analysis indicated clinical chorioamnionitis and elevated maternal WBC count on admission to be associated with ROP occurrence [odds ratio (OR) = 4.370, P = 0.046; and OR = 1.104 per 1,000 cells/mm(3) incremental increase, P = 0.019, respectively], while the use of tocolytics was associated with reduced occurrence of ROP (OR = 0.278, P = 0.006). Elevated maternal WBC count on admission was also independently associated with ROP progression requiring laser treatment (OR = 1.171 per 1,000 cells/mm(3) incremental increase, P = 0.026). However, neither histologic chorioamnionitis nor funisitis was associated with the occurrence or progression of ROP. CONCLUSIONS: Clinical chorioamnionitis and elevated maternal WBC count, but not histologic chorioamnionitis, were significantly and independently associated with ROP. These findings support the hypothesis that maternal systemic inflammation may play a role in the pathogenesis of ROP.
Se Joon Woo; Kyo Hoon Park; Hee Jung Jung; Shi Nae Kim; Gheeyoung Choe; Jeeyun Ahn; Kyu Hyung Park
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-1
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie     Volume:  -     ISSN:  1435-702X     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
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