Document Detail

Effects of maternal nuclear genome on the timing of puberty in mice offspring.
MedLine Citation:
PMID:  17535878     Owner:  NLM     Status:  MEDLINE    
The timing of puberty is a complex trait which is regulated by environmental and genetic factors, but the detailed regulatory mechanism remains elusive. Maternal nutrition administration during late gestation in rats revealed that the time of onset of puberty in daughter rats was influenced by the mother's nutritional and physiological status during the embryonic development period. In this study, the potential effects of the maternal nuclear genome on the timing of puberty of offspring were investigated. Two inbred strains of mice (C3H/HeJ (C3H) and C57BL/6J (B6)) were used to set up two pedigrees (direct and reciprocal crosses), and the timing of puberty in all these mice (parent, F1 and F2) was recorded (the females were assessed by vaginal opening (VO) and the males by balano preputial separation (BPS)). The results from data of 822 mice showed that: 1) in female mice, the heritability of the timing of puberty in direct and reciprocal crosses is 68.51% and 63.97% respectively; 2) in female mice, a significant difference in the timing of puberty is observed between B6 and C3H (P = 3.7 x 10(-13)) mice as well as between direct and reciprocal F1 hybrids (P = 5.4 x 10(-3)), but not between direct and reciprocal F2 hybrids (P = 0.0941); 3) in male mice, direct and reciprocal F1 hybrids differ significantly from each other in the timing of BPS (P = 2.7 x 10(-7)), while such differences vanish in their male progenitor and progeny. The significant discrepancy between direct and reciprocal crosses in F1 but not in either cross of F2 hybrids reveals that the maternal nuclear genome has effects on the timing of puberty in mice progeny, probably through imprinting genes or the genes associated with intra-uterine physiological status.
Yuxun Zhou; Wangsheng Zhu; Zhengxia Guo; Ying Zhao; Zijun Song; Junhua Xiao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  193     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-30     Completed Date:  2007-08-07     Revised Date:  2007-09-04    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  405-12     Citation Subset:  IM    
Institute of Bioscience and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.
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MeSH Terms
Aging / genetics*,  physiology
Fertility / genetics
Fetal Development / genetics
Genomic Imprinting*
Hybridization, Genetic
Mice, Inbred C3H
Mice, Inbred C57BL
Oocytes / physiology*
Quantitative Trait, Heritable*
Species Specificity
Erratum In:
J Endocrinol. 2007 Aug;194(2):457

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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