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Effects of maternal mild zinc deficiency and zinc supplementation in offspring on spatial memory and hippocampal neuronal ultrastructural changes.
MedLine Citation:
PMID:  23312766     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: Knowledge about the hippocampal morphologic mechanisms of learning and memory for maternal mild zinc deficiency during pregnancy/lactation followed by zinc supplementation of pups after weaning is limited. This study examined the effects of zinc deficiency and zinc supplementation on cognition and hippocampal neurons.
METHODS: One-day pregnant rats were randomly divided into four groups (n = 12): control (CO), pair-fed (PF), zinc-deprived (ZD), and oral zinc-supplemented (OZS). The CO and PF groups were fed a control diet (zinc 25 μg/g diet), and the others were fed a mildly zinc-deficient diet (zinc 2 μg/g diet) during pregnancy and lactation. After weaning (day 21), offspring in the OZS group were switched to a control diet. After 35 d, the behavioral function of the offspring was tested with the Morris water maze test. The ultrastructure of the hippocampal CA3 area was observed under a transmission electron microscope.
RESULTS: Compared with the CO and PF groups, rats in the ZD group spent more time finding the latent platform and swam longer distances (P < 0.05). The time used finding the platform and the swimming distance in the OZS group were similar to those in the CO and PF groups (P > 0.05). In addition, apoptotic neuronal changes in the hippocampus were observed in the ZD group, whereas the reversal of neuronal morphologic changes was observed in the OZS group.
CONCLUSION: The changes in hippocampal neuron morphology were consistent with the changes in the learning and memory ability of mildly zinc-deficient and zinc-supplemented offspring.
Xiaodan Yu; Longmei Jin; Xiaohua Zhang; Xiaogang Yu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  29     ISSN:  1873-1244     ISO Abbreviation:  Nutrition     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  457-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
MOE-Shanghai Key Laboratory of Children's Environmental Health, Shanghai Institute for Pediatric Research, XinHua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
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