| Effects of maternal lead administration on monoaminergic, GABAergic and glutamatergic systems. | |
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MedLine Citation:
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PMID: 12242099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of perinatal exposure to lead (300 mg/l) on the development of monoaminergic and aminoacidergic systems were evaluated in the striatum, cerebral cortex (Cx), dorsal hippocampus (d-Hipp) and basal-medial hypothalamus. Maternal exposure to lead produced regional alterations in monoamine content, with increases in dopamine and serotonin or their metabolites. Further, decreased glutamate levels were seen in all brain regions studied, while GABA content decreased only in the Cx. Together, these results show that lead causes alterations to neurotransmitter systems during development. These may be related to lead-induced neurobehavioral impairment. |
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Authors:
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M L Leret; F Garcia-Uceda; M T Antonio |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research bulletin Volume: 58 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-09-20 Completed Date: 2002-11-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: United States |
Other Details:
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Languages: eng Pagination: 469-73 Citation Subset: IM |
Affiliation:
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Department of Animal Biology-II (Animal Physiology), Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain. mantonio@eumax.sim.ucm.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biogenic Monoamines / analysis* Brain / drug effects*, embryology, metabolism* Cerebral Cortex / drug effects, metabolism Corpus Striatum / drug effects, metabolism Dopamine / analysis Female Glutamic Acid / analysis* Hippocampus / drug effects, metabolism Hypothalamus, Middle / drug effects, metabolism Lead Poisoning / metabolism* Maternal Exposure* Maternal-Fetal Exchange Organ Specificity Pregnancy Rats Rats, Wistar Serotonin / analysis gamma-Aminobutyric Acid / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Biogenic Monoamines; 50-67-9/Serotonin; 56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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