Document Detail


Effects of maternal labetalol on the newborn infant.
MedLine Citation:
PMID:  1291496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forty eight neonates, born to mothers suffering from pregnancy induced hypertension and receiving labetalol for control of blood pressure, were studied for the possible adverse effects of the drug. These were compared with eighty one neonates matched for gestation and weight and born to mothers with pregnancy induced hypertension treated with drugs other than labetalol. Incidence of birth asphyxia and intrauterine growth retardation (IUGR) in the study population was 10.4 and 22.9%, respectively and in the control group 5 and 19.7%, the difference between two groups was not statistically significant (p > 0.05). However, the incidence of hypoglycemia was significantly higher (p < 0.01) in the study group (47.9%) as compared to the control group (17.2%). Two-thirds of the hypoglycemic babies in the study population were asymptomatic and they were managed with sugar-fortified milk feeds. In the study population, the symptomatic hypoglycemic babies had hypoglycemia for prolonged duration of 43.3 +/- 23.3 hours as compared to 11.5 +/- 6.3 hours in symptomatic hypoglycemic babies of the control group (p < 0.01). The mothers of the symptomatic babies in the study group received higher doses of labetalol in the range of 287.6 +/- 142.3 mg/day while rest of the mothers in the same group whose babies had either asymptomatic hypoglycemia or normal blood glucose levels, received 239.5 +/- 118.5 mg/day, though the difference was not statistically significant. It is concluded that maternal labetalol therapy is associated with increased risk of neonatal hypoglycemia.
Authors:
U K Munshi; A K Deorari; V K Paul; M Singh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian pediatrics     Volume:  29     ISSN:  0019-6061     ISO Abbreviation:  Indian Pediatr     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-04-01     Completed Date:  1993-04-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  1507-12     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
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MeSH Terms
Descriptor/Qualifier:
Asphyxia Neonatorum / chemically induced
Female
Fetal Growth Retardation / chemically induced
Humans
Hypertension / drug therapy*
Hypoglycemia / chemically induced*
Incidence
Infant, Newborn
Labetalol / adverse effects*
Maternal-Fetal Exchange
Pregnancy
Pregnancy Complications, Cardiovascular / drug therapy*
Chemical
Reg. No./Substance:
36894-69-6/Labetalol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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