Document Detail

Effects of maternal infection on prostaglandin production and uterine contraction in late-gestation pregnant goats.
MedLine Citation:
PMID:  9366146     Owner:  NLM     Status:  MEDLINE    
The main objective of this study was to evaluate the relationship between maternal infection induced by pyrogen administration and the changes in maternal and fetal plasma levels of prostaglandin E2 (PGE2) and F 2 alpha (PGF 2 alpha) and uterine contraction. We administered one mg of pyrogen (E. coli endotoxin) into the maternal femoral vein; then then the changes in maternal and fetal core temperatures, plasma levels of PGE2, [PGE2] and PGF 2 alpha, [PGF 2 alpha]. pO2, pCO2, pH and maternal uterine contractions were measured in late-gestation pregnant goats (n = 8). Maternal and fetal core temperatures were elevated significantly 30 min after pyrogen administration (p < 0.05), reached their peak levels after 3 hours, and after 5 hours mean core temperatures returned to levels indistinguishable from initial control. Maternal plasma [PGE2] and [PGF 2 alpha] increased to 4318 +/- 321 pg/ml after 1 hour and to 670.8 +/- 58.4 pg/ml after 3 hours respectively (p < 0.05). Fetal plasma [PGF 2 alpha] increased significantly (p < 0.05) to 811.0 +/- 64.0 pg/ml after 1 hour; however, plasma [PGE2] did not change throughout the study. Periodic uterine contractions appeared after 3 hours and disappeared after 5 hours. These results suggest that pyrogen induces the elevation of maternal and fetal core temperatures and prostaglandin production, and that eventually causes uterine contractions.
K Tanaka; T Kawamura; H Asakura; T Araki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nihon Ika Daigaku zasshi     Volume:  64     ISSN:  0048-0444     ISO Abbreviation:  Nippon Ika Daigaku Zasshi     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-01-21     Completed Date:  1998-01-21     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  7505726     Medline TA:  Nihon Ika Daigaku Zasshi     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  422-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.
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MeSH Terms
Body Temperature
Carbon Dioxide / blood
Dinoprost / blood*
Dinoprostone / blood*
Fetal Blood / metabolism
Gestational Age
Hydrogen-Ion Concentration
Maternal-Fetal Exchange
Oxygen / blood
Pregnancy Complications, Infectious / physiopathology*
Pyrogens / toxicity
Uterine Contraction*
Reg. No./Substance:
0/Pyrogens; 124-38-9/Carbon Dioxide; 363-24-6/Dinoprostone; 551-11-1/Dinoprost; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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