Document Detail


Effects of maternal gestational diabetes and adiposity on neonatal adiposity and blood pressure.
MedLine Citation:
PMID:  7497855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the effects of maternal factors, including prepregnancy maternal adiposity, weight gain during pregnancy, degree of abnormality of the glucose tolerance test, glycemia during pregnancy, and treatment with insulin versus diet therapy, on neonatal body weight, adiposity, and blood pressure in infants of mothers with gestational diabetes (IGDM) and control patients. RESEARCH DESIGN AND METHODS: A total of 119 term IGDM, including 57 large-for-gestational-age (LGA) and 62 appropriate-for-gestational-age (AGA) infants, and 143 term control infants, including 74 LGA and 69 AGA infants, were prospectively enrolled. Maternal measurements of prepregnancy weight, height, and weight gain were abstracted from medical records. A diagnosis of gestational diabetes was made on the basis of an initial 1-h 50-g glucose screen value > or = 130 mg/dl followed by two abnormal values in a 100-g oral glucose tolerance test. Infant anthropometric measurements were obtained, and blood pressure was measured on day 2 of life. Correlation analyses and multiple regression analyses were performed to assess the relationships among maternal factors and neonatal adiposity and blood pressure. RESULTS: Multiple regression analyses to determine the effects of significant maternal factors on infant body mass index (BMI) revealed that prepregnancy weight and weight gain were significant predictors for both IGDM and control infants. An increased glucose screen predicted BMI for control subjects, whereas the mean 2nd and 3rd trimester glucose values were the significant predictors for IGDM. Also, increased newborn triceps skinfold thickness measurements correlated with increased systolic blood pressure for IGDM (r = 0.29, P < 0.03). CONCLUSIONS: Increased maternal prepregnancy weight, weight gain in pregnancy, and glycemia in pregnancy all place IGDM at increased risk of macrosomia and adiposity. Increased adiposity in the IGDM appears to be related to increased infant blood pressure. Longitudinal evaluation is needed to determine whether neonatal adiposity in IGDM is predictive of increased adiposity and blood pressure during childhood.
Authors:
B R Vohr; S T McGarvey; C G Coll
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Diabetes care     Volume:  18     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1996-01-18     Completed Date:  1996-01-18     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  467-75     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Miriam Hospital, Providence, Rhode Island, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / anatomy & histology*
Adult
Blood Pressure*
Body Mass Index
Diabetes, Gestational / physiopathology*,  therapy
Diabetic Diet
Female
Gestational Age
Glucose Tolerance Test
Humans
Infant, Newborn / physiology*
Insulin / therapeutic use
Predictive Value of Tests
Pregnancy
Prospective Studies
Regression Analysis
Risk Factors
Weight Gain
Grant Support
ID/Acronym/Agency:
2P5O-HD-11343/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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