| Effects of maternal ethanol consumption on the offspring sensory-motor development, ultrasonic vocalization, audiogenic immobility reaction and brain monoamine synthesis. | |
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MedLine Citation:
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PMID: 2863919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Female rats were given 16% ethanol solution as the sole liquid during the entire period of gestation. At birth the offspring was removed and reared by foster dams consuming normal tap water. The development of sensory motor behaviour and emotional reactions was delayed by 1-2 days in the prenatally ethanol exposed pups as assessed by tests on body righting, acoustic startle response, air righting, rearing and ultrasonic vocalization. In the open-field test the normally occurring behavioural difference between the sexes was not found in the prenatally ethanol exposed pups. Both sexes of the ethanol exposed pups behaved like the female controls suggesting deficient masculinization of the ethanol exposed male pups during foetal age. Biochemical analysis of the brains showed a decreased synthesis of serotonin and dopamine. |
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Authors:
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E Hård; J Engel; K Larsson; S Liljequist; B Musi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta pharmacologica et toxicologica Volume: 56 ISSN: 0001-6683 ISO Abbreviation: Acta Pharmacol Toxicol (Copenh) Publication Date: 1985 May |
Date Detail:
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Created Date: 1985-09-30 Completed Date: 1985-09-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370572 Medline TA: Acta Pharmacol Toxicol (Copenh) Country: DENMARK |
Other Details:
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Languages: eng Pagination: 354-63 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism Animals Biogenic Amines / biosynthesis* Body Weight / drug effects Brain / drug effects*, metabolism Ethanol / toxicity* Female Fetus / drug effects* Immobilization* Male Motor Activity / drug effects* Pregnancy Rats Rats, Inbred Strains Sex Factors Tyrosine 3-Monooxygenase / analysis Ultrasonics Vocalization, Animal / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Biogenic Amines; 64-17-5/Ethanol; EC 1.14.16.2/Tyrosine 3-Monooxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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