| Effects of maternal diabetes on the development of carbohydrate-metabolizing enzymes, glycogen deposition and surface active phospholipid levels in fetal rat lung. | |
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MedLine Citation:
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PMID: 6303458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Streptozotocin-induced maternal diabetes has been shown to alter developmental patterns of carbohydrate-metabolizing enzyme activities, glycogen deposition and surfactant levels in late fetal rat lung in a tissue-specific manner, as follows: (a) marked reduction in glycogen synthase a activity, due to aberrant interconversion between active and inactive forms of the enzyme; less glycogen was thus accumulated; (b) lowered activities of hexokinase, phosphofructokinase and pyruvate kinase at term; (c) reduced disaturated phosphatidylcholine (surfactant) concentrations. The diminished synthesis and accumulation of glycogen and glycolytic capacity in the lungs of fetuses of diabetic mothers has been related to reduction in surfactant level, which underlies respiratory distress syndrome frequently encountered in neonates of diabetic pregnancies. |
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Authors:
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M Singh; M Feigelson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biology of the neonate Volume: 43 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 1983 |
Date Detail:
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Created Date: 1983-07-15 Completed Date: 1983-07-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 33-42 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Mellitus, Experimental / embryology*, metabolism Female Glycogen / metabolism* Glycogen Synthase / metabolism Lung / embryology, enzymology* Phosphorylases / metabolism Phosphotransferases / metabolism Pregnancy Pregnancy in Diabetics / embryology*, metabolism Pulmonary Surfactants / metabolism* Rats |
| Grant Support | |
ID/Acronym/Agency:
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AM-28567/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Pulmonary Surfactants; 9005-79-2/Glycogen; EC 2.4.1.-/Phosphorylases; EC 2.4.1.11/Glycogen Synthase; EC 2.7.-/Phosphotransferases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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