Document Detail

Effects of maternal dexamethasone administration on fetal Doppler flow velocity waveforms.
MedLine Citation:
PMID:  10759269     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the effects of maternal dexamethasone administration on umbilical and fetal cerebral artery flow velocity waveforms. DESIGN: Cross-sectional study. SETTING: Department of Obstetrics and Gynaecology, Robert Ballanger Hospital, Aulnay-sous-Bois, France. SAMPLE: Twenty-six pregnant women with singleton pregnancies considered at risk for preterm delivery. At baseline, all pregnancies had normal fetoplacental vascular resistance. METHODS: These women were given weekly six intravenous doses of 4 mg of dexamethasone eight hours apart. MAIN OUTCOME MEASURES: Doppler studies were performed from both umbilical artery (UA) and fetal middle cerebral artery (MCA) before (day 0), during (day 2), immediately after (day 4) and shortly after (day 7) every steroid course. RESULTS: No significant variation was noted in both umbilical artery pulsatility index (PI) and fetal heart rate through dexamethasone therapy. Compared with mean initial values, we found on day 4 a significant decrease in MCA PI of 0.28 (F = 7.17, P < 0.001) and a significant increase in UA:MCA PI ratio of 0.08 (F = 3.85, P = 0.013); in contrast no significant change was documented on days 2 and 7 in both MCA pulsatility index and UA:MCA PI ratio. After multiple regression analysis, only the decrease in fetal middle cerebral artery pulsatility index on day 4 remained significant (F= 5.84, P= 0.001). CONCLUSIONS: The current study finds in healthy fetuses a transient, significant and unexplained decrease in fetal middle cerebral artery impedance on the fourth day following maternal dexamethasone administration. Further basic research and clinical studies including larger sample sizes or pregnancies with fetoplacental dysfunction are needed.
Y Chitrit; P Caubel; R Herrero; A L Schwinte; D Guillaumin; M C Boulanger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  107     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-04-20     Completed Date:  2000-04-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  501-7     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, Robert Ballanger Hospital, Aulnay-sous-Bois, France.
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MeSH Terms
Cross-Sectional Studies
Dexamethasone / pharmacology*
Glucocorticoids / pharmacology*
Maternal-Fetal Exchange
Middle Cerebral Artery / drug effects*,  ultrasonography
Regression Analysis
Ultrasonography, Prenatal / drug effects*
Umbilical Arteries / drug effects*,  ultrasonography
Reg. No./Substance:
0/Glucocorticoids; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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