Document Detail

Effects of maternal cigarette smoking and alcohol consumption on blood lead levels of newborns.
MedLine Citation:
PMID:  9012598     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to evaluate the effect of cigarette smoking (active and passive exposure) and alcohol consumption during pregnancy on cord blood lead levels. In 1990, a survey was conducted in two hospitals in Québec City, Québec, Canada, a white-collar agglomeration. The sample included 430 mothers and their newborns. Information on the lifestyles of mothers during pregnancy was obtained by questionnaire. Cord blood lead concentrations were measured by atomic absorption spectrophotometry. A dose-response relation was found between cigarette smoking and alcohol consumption of mothers and cord blood lead levels. An average increase of about 15 percent (0.013 mumol/liter) in cord blood lead levels was estimated for every 10 cigarettes smoked per day. Mean blood lead levels in babies whose mothers did not smoke during pregnancy but who drank alcohol moderately was 17 percent higher than those of nonsmoking mothers who abstained from alcohol intake. Multivariate analyses revealed that both cigarette smoking and alcohol intake make significant and independent contributions to cord blood lead concentrations. Lifestyles of pregnant women thus appear to play an important role in the prenatal lead exposure of newborns. Because of the potential effects of lead exposure on pregnancy outcomes, our study provides further arguments to support public health advisories concerning the harmful effect of smoking and drinking alcohol during pregnancy.
M Rhainds; P Levallois
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of epidemiology     Volume:  145     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-02-21     Completed Date:  1997-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  250-7     Citation Subset:  IM    
Service Santé, Centre Hospitalier universitaire de Québec, Beauport, Canada.
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MeSH Terms
Alcohol Drinking / adverse effects*
Fetal Blood / chemistry*
Infant, Newborn
Lead / blood*
Life Style
Middle Aged
Multivariate Analysis
Pregnancy Complications*
Smoking / adverse effects*
Spectrophotometry, Atomic
Tobacco Smoke Pollution / adverse effects*
Reg. No./Substance:
0/Tobacco Smoke Pollution; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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