| Effects of malnutrition on some aspects of RNA metabolism in the maternal liver and fetal tissues at different stages of pregnancy in the rat. | |
| | |
MedLine Citation:
|
PMID: 894366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A comparison was made between rats fed diets containing either 5% casein or 25% casein, both being supplemented with DL-methionine, from the first day of pregnancy. Livers of dams killed on days 7, 14, and 21 and whole fetuses on days 12, 14, and 21 were weighed, analyzed for protein, RNA and DNA content and assayed for ornithine decarboxylase (ODC) and S-adenosyl-L-methionine decarboxylase (SAMD). Free and total alkaline ribonuclease activity were also measured in the maternal livers. Malnutrition reduced the characteristic increase in content of DNA, RNA and protein in the maternal liver and fetus. In control rats total hepatic RNase activity increased and free RNase activity decreased during late pregnancy. In the deprived group, total activity decreased and free activity increased during late pregnancy. Liver and fetal ODC and SAMD activities were reduced by undernutrition. These studies show that malnutrition reduced both growth and the accretion of RNA in livers and fetuses of rat dams. These changes coincide with a reduced activity of polyamine synthesizing enzymes suggesting that there is a functional relationship between polyamines and RNA. High hepatic free RNase activity in malnourished dams may help to limit any build up in RNA content. |
| | |
Authors:
|
B L Morgan; M Winick |
Related Documents
:
|
7943326 - Developmentally regulated gb3 galactosyltransferase and alpha-galactosidase determine s... 8498156 - Individual and combined effects of intact pth, amino-terminal, and a series of truncate... 21475966 - Placental α-microglobulin-1 to detect uncertain rupture of membranes in a european coh... 1348996 - Plasminogen activators and inhibitors in normal late pregnancy, postpartum and in the p... 11158056 - Pregnancy-associated plasma protein-a accounts for the insulin-like growth factor (igf)... 17010146 - Maternal oral intake mouse model for fetal alcohol spectrum disorders: ocular defects a... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of nutrition Volume: 107 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1977 Sep |
Date Detail:
|
Created Date: 1977-10-31 Completed Date: 1977-10-31 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1694-701 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosylmethionine Decarboxylase
/
metabolism Animals Body Weight Caseins Female Fetus / metabolism* Gestational Age Liver / anatomy & histology, metabolism* Methionine Nucleic Acids / metabolism* Organ Size Ornithine Decarboxylase / metabolism Pregnancy Pregnancy Complications / metabolism* Protein Deficiency / metabolism* Proteins / metabolism Rats Ribonucleases / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Caseins; 0/Nucleic Acids; 0/Proteins; 63-68-3/Methionine; EC 3.1.-/Ribonucleases; EC 4.1.1.17/Ornithine Decarboxylase; EC 4.1.1.50/Adenosylmethionine Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic influence on zinc metabolism in mice.
Next Document: Analysis of chromium induced carbohydrate intolerance in the rat.