Document Detail

Effects of malnutrition on some aspects of RNA metabolism in the maternal liver and fetal tissues at different stages of pregnancy in the rat.
MedLine Citation:
PMID:  894366     Owner:  NLM     Status:  MEDLINE    
A comparison was made between rats fed diets containing either 5% casein or 25% casein, both being supplemented with DL-methionine, from the first day of pregnancy. Livers of dams killed on days 7, 14, and 21 and whole fetuses on days 12, 14, and 21 were weighed, analyzed for protein, RNA and DNA content and assayed for ornithine decarboxylase (ODC) and S-adenosyl-L-methionine decarboxylase (SAMD). Free and total alkaline ribonuclease activity were also measured in the maternal livers. Malnutrition reduced the characteristic increase in content of DNA, RNA and protein in the maternal liver and fetus. In control rats total hepatic RNase activity increased and free RNase activity decreased during late pregnancy. In the deprived group, total activity decreased and free activity increased during late pregnancy. Liver and fetal ODC and SAMD activities were reduced by undernutrition. These studies show that malnutrition reduced both growth and the accretion of RNA in livers and fetuses of rat dams. These changes coincide with a reduced activity of polyamine synthesizing enzymes suggesting that there is a functional relationship between polyamines and RNA. High hepatic free RNase activity in malnourished dams may help to limit any build up in RNA content.
B L Morgan; M Winick
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  107     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-10-31     Completed Date:  1977-10-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1694-701     Citation Subset:  IM    
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MeSH Terms
Adenosylmethionine Decarboxylase / metabolism
Body Weight
Fetus / metabolism*
Gestational Age
Liver / anatomy & histology,  metabolism*
Nucleic Acids / metabolism*
Organ Size
Ornithine Decarboxylase / metabolism
Pregnancy Complications / metabolism*
Protein Deficiency / metabolism*
Proteins / metabolism
Ribonucleases / metabolism
Reg. No./Substance:
0/Caseins; 0/Nucleic Acids; 0/Proteins; 63-68-3/Methionine; EC 3.1.-/Ribonucleases; EC Decarboxylase; EC Decarboxylase

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