| Effects of magnesium sulfate on preterm fetal cerebral blood flow using Doppler analysis: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 20027029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To estimate the effects of maternal administration of magnesium sulfate on the fetal middle cerebral artery using Doppler. METHODS: This is a single-center ancillary study done in conjunction with a randomized, double-masked, placebo- controlled trial in 20 centers. Women at imminent risk of preterm delivery (n=2,241) were allocated randomly to receive magnesium sulfate or placebo. Doppler measurements of the fetal middle cerebral artery were obtained before blinded study-drug administration and subsequently at 1-, 2-, 3-, and 4-hour intervals. Parameters studied included time-average velocity, peak systolic velocity, vessel diameter, heart rate, and calculated blood volume flow. A random-effects model with repeated-measures design was used for analysis. RESULTS: A total of 38 fetuses were studied: 18 received magnesium sulfate and 20 received placebo. Peak systolic velocity was significantly related to gestational age (P<.001). There were no differences between the study groups for middle cerebral artery peak systolic velocity, average velocity, vessel diameter, or calculated volume flow. However, fetal heart rate significantly decreased after treatment with magnesium sulfate. CONCLUSION: Magnesium sulfate had no significant effects on fetal cerebral blood flow analyzed using Doppler. The only parameter in the fetal cerebral circulation significantly modified by magnesium sulfate was the heart rate. The significance of this heart-rate change, vis-à-vis the neuroprotective effects of magnesium sulfate, is unknown. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials.gov, NCT00014989. LEVEL OF EVIDENCE: I. |
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Authors:
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Diane M Twickler; Donald D McIntire; James M Alexander; Kenneth J Leveno |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 115 ISSN: 1873-233X ISO Abbreviation: Obstet Gynecol Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-22 Completed Date: 2010-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 21-5 Citation Subset: AIM; IM |
Affiliation:
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University of Texas Southwestern Medical Center, Departments of Radiology and Obstetrics and Gynecology, Dallas, Texas 75235-9032, USA. diane.twickler@utsouthwestern.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00014989 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Circle of Willis / embryology, ultrasonography Female Fetal Heart / physiology Fetus / physiology* Heart Rate / physiology Humans Magnesium Sulfate / pharmacology* Middle Cerebral Artery / embryology, physiology* Pregnancy Regional Blood Flow / drug effects Tocolytic Agents / pharmacology* Ultrasonography, Doppler Ultrasonography, Prenatal* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Tocolytic Agents; 7487-88-9/Magnesium Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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