Document Detail

Effects of magnesium orotate on rat heart function.
MedLine Citation:
PMID:  8204799     Owner:  NLM     Status:  MEDLINE    
Female Sprague-Dawley rats were given magnesium orotate (100 mg/kg/day) by gavage for 7 days. The effects on left ventricular, right ventricular, and circulatory function were measured using Millar ultraminiature catheter pressure transducers and thermodilution. In another series, rats were pretreated for 4 days with magnesium orotate. Then they received an intravenous infusion of norepinephrine (0.2 mg/kg/h) for 3 days while magnesium orotate treatment was continued. Thereafter, left ventricular function was examined. Magnesium orotate given for 7 days in control rats induced an increase in heart rate from 380 +/- 18 (n = 7) to 415 +/- 9 beats/min (n = 8); in left ventricular systolic pressure from 165 +/- 8 to 183 +/- 10 mmHg; in left ventricular dP/dtmax from 11486 +/- 1082 to 13300 +/- 909 mmHg/s; and in cardiac output from 386 +/- 38 to 429 +/- 16 ml/kg/min. The pressure-rate product was significantly elevated by magnesium orotate from 54956 +/- 4260 to 66094 +/- 3703 mmHg/min (p < 0.05). Right ventricular systolic pressure was also significantly increased from 34 +/- 1 to 41 +/- 3 mmHg (p < 0.05), and right ventricular dP/dtmax was increased from 2233 +/- 167 to 2857 +/- 489 mmHg/s. Infusion of norepinephrine for 3 days induced an increase in heart rate by 34%, in left ventricular systolic pressure by 10%, in left ventricular dP/dtmax by 88%, in right ventricular systolic pressure by 147%, and in right ventricular dP/dtmax by 100%. Magnesium orotate treatment did not significantly affect the changes induced by norepinephrine.(ABSTRACT TRUNCATED AT 250 WORDS)
H G Zimmer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardioscience     Volume:  5     ISSN:  1015-5007     ISO Abbreviation:  Cardioscience     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-07-13     Completed Date:  1994-07-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9014943     Medline TA:  Cardioscience     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  55-61     Citation Subset:  IM    
Department of Physiology, University of Munich, Germany.
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MeSH Terms
Heart / drug effects*
Heart Catheterization
Hemodynamics / drug effects*
Myocardium / metabolism
Norepinephrine / pharmacology
Orotic Acid / pharmacology*
Rats, Sprague-Dawley
Time Factors
Ventricular Function / drug effects*
Reg. No./Substance:
51-41-2/Norepinephrine; 65-86-1/Orotic Acid

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